Email this article STUDY OF TOXICITY OF SAKHABACTISUBTIL IN RATS
- Authors: Neustroev M.P.1, Murashev A.N.2, Bondarenko D.A.2, Stepanova A.M.1, Tarabukina N.P.1
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Affiliations:
- Research Institute of Agriculture
- Branch of Shemyakin and Ovchinnikov Research Institute of Bioorganic Chemistry
- Issue: Vol 94, No 5 (2017)
- Pages: 59-64
- Section: ORIGINAL RESEARCHES
- Submitted: 10.04.2019
- Published: 28.10.2017
- URL: https://microbiol.crie.ru/jour/article/view/204
- DOI: https://doi.org/10.36233/0372-9311-2017-5-59-64
- ID: 204
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Abstract
Aim. Determine safety and potential toxic effects of Sakhabactisubtil during its multifold intra-gastric administration to CD rats. Materials and methods. Male and female CD rats (Sprague-Dawley) of various experimental groups received various doses of the preparation or saline (control group) once per day (twice for group 3 in 8 mi at 6 hours interval) intra-gastrically for 14 days. Body mass, forage use, clinical signs were determined for 14 days of the preparation administration and 14 days after cancellation in all the animals. The animals were euthanized and necropsy was carried out at days 15 and 29 of the study with extraction of organs for subsequent histological analysis. Mass of internal organs was registered during necropsy, blood samples were taken for study of hematologic and biochemical parameter evaluation. Results. Animal death and signs of toxicity were not detected during the study from administration of the tested preparation for the entire period. Statistically significant differences between groups by body mass growth, hematologic and biochemical parameters were not detected. Conclusion. Sakhabactisubtil is safe during multifold intra-gastric administration to CD rats.
About the authors
M. P. Neustroev
Research Institute of Agriculture
Author for correspondence.
Email: noemail@neicon.ru
Россия
A. N. Murashev
Branch of Shemyakin and Ovchinnikov Research Institute of Bioorganic Chemistry
Email: noemail@neicon.ru
Россия
D. A. Bondarenko
Branch of Shemyakin and Ovchinnikov Research Institute of Bioorganic Chemistry
Email: noemail@neicon.ru
Россия
A. M. Stepanova
Research Institute of Agriculture
Email: noemail@neicon.ru
Россия
N. P. Tarabukina
Research Institute of Agriculture
Email: noemail@neicon.ru
Россия
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