MOLECULAR-EPIDEMIOLOGICAL MONITORING OF ENTEROVIRUS CIRCULATION IN THE FAR EAST AND ZABAIKALYE


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Abstract

6 year molecular-biological monitoring of enteroviruses in the Far East and Zabaikalye was carried out. Nucleotide sequence of 125 strains was determined from 2006 to 2011. Molecular analysis was carried out in VP1 virus genome region. Phylogenetic interactions for ECHO-6, ECHO-30, ECHO-11, Coxsackie B-5 (CB-5), Coxsackie B-1 (CB-1) and Coxsackie A-9 (CA-9) were analyzed. Highly dynamic epidemiology was shown to be inherent for ECHO-6 and ECHO-30 viruses and is characterized by genetic heterogeneity and consequent change of virus variants. On the contrary a relative stability of circulating genotypes is in- trinsic for CB-1, CB-5 and ECHO-11 enteroviruses. The results of molecular-biological studies indicate frequent introduction of new enterovirus variants from countries of Europe and Asia.

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МОЛЕКУЛЯРНО-ЭПИДЕМИОЛОГИЧЕСКИЙ МОНИТОРИНГ ЦИРКУЛЯЦИИ ЭНТЕРОВИРУСОВ НА ДАЛЬНЕМ ВОСТОКЕ И В ЗАБАЙКАЛЬЕ
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About the authors

O. E Trotsenko

Khabarovsk Research Institute of Epidemiology and Microbiology

A. N Lukashev

Chumakov Research Institute of Poliomyelitis and Viral Encephalitis, Moscow Region

T. N Karavyanskaya

Department of Federal Service for Surveillance for Protection of Consumers' Rights and Human Welfare of Khabarovsk Region

V. I Reznik

Centre of Hygiene and Epidemiology of Khabarovsk Region, Russia

E. Yu Sapega

Khabarovsk Research Institute of Epidemiology and Microbiology

V. O Kotova

Khabarovsk Research Institute of Epidemiology and Microbiology

E. N Amyaga

Khabarovsk Research Institute of Epidemiology and Microbiology

P. V Korita

Khabarovsk Research Institute of Epidemiology and Microbiology

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Copyright (c) 2013 Trotsenko O.E., Lukashev A.N., Karavyanskaya T.N., Reznik V.I., Sapega E.Y., Kotova V.O., Amyaga E.N., Korita P.V.

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