CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

V. B. Polischuk; Полищук В. Б.; A. A. Ryzhov; Рыжов А. А.; M. P. Kostinov; Костимов М. П.; O. O. Magarshak; Магаршак О. О.; A. D. Shmitko; Шмитько А. Д.; I. V. Vlukachev; Лукачев И. В.; G. V. Vasileva; Васильева Г. В.; D. A. Blagovidov; Благовидов Д. А.; A. G. Chuchalin; Чучалин А. Г.; S. N. Avdeev; Авдеев С. Н.; N. A. Karchevskaya; Карчевская Н. А.

doi:10.36233/0372-9311-2016-4-55-60

CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

Authors: Polischuk V.B.¹, Ryzhov A.A.¹, Kostinov M.P.¹, Magarshak O.O.¹, Shmitko A.D.¹, Vlukachev I.V.¹, Vasileva G.V.¹, Blagovidov D.A.¹, Chuchalin A.G.², Avdeev S.N.², Karchevskaya N.A.²
Affiliations:
1. Mechnikov Research Institute of Vaccines and Sera
2. Research Institute of Pulmonology
Issue: Vol 93, No 4 (2016)
Pages: 55-60
Section: ORIGINAL RESEARCHES
URL: https://microbiol.crie.ru/jour/article/view/70
DOI: https://doi.org/10.36233/0372-9311-2016-4-55-60
ID: 70

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Abstract

Aim. Determination of intensity of immunity against measles in patients on waiting-list for lung transplantation. Materials and methods. IgG levels against measles virus were studied in blood sera of 80 adult patients (mean age 35.8± 11.4 years) on waiting-list of lung transplantation, without history of this disease. Determination of IgG levels against measles virus was carried out by ELISA using a standard kit from «Vektor-Best» (VectoMeasles-IgG). Results. Protective level of IgG against measles virus (above 0.18 I U/ml) was registered in 83.3% of examined patients. Mean level of anti-measles antibodies was within protective values - 1.53 IU/ml (95% confidence interval 1.17 - 1.89). Medium level of anti-measles antibodies (1 - 5 IU/ml) was registered in most of the analyzed samples (55.2%). A positive correlation between values of antibodies and age of patients (r=0.43) was detected. Dependence between levels of antibodies and previously executed hormonal and cytostatic therapy was not detected. Conclusion. Patients on waiting-list of solid organ transplantation are a group of risk for development of severe course of measles infection, that dictates the necessity of execution of vaccination at short terms before or after registration on the waiting-list.

Keywords

vaccine-controlled infections, measles, lung transplantation, anti-measles antibodies, immune-competent patients

References

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CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

Full Text

Abstract

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About the authors

References

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