CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

V. B. Polischuk; Полищук В. Б.; A. A. Ryzhov; Рыжов А. А.; M. P. Kostinov; Костимов М. П.; O. O. Magarshak; Магаршак О. О.; A. D. Shmitko; Шмитько А. Д.; I. V. Vlukachev; Лукачев И. В.; G. V. Vasileva; Васильева Г. В.; D. A. Blagovidov; Благовидов Д. А.; A. G. Chuchalin; Чучалин А. Г.; S. N. Avdeev; Авдеев С. Н.; N. A. Karchevskaya; Карчевская Н. А.

doi:10.36233/0372-9311-2016-4-55-60

CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

Authors: Polischuk V.B.¹, Ryzhov A.A.¹, Kostinov M.P.¹, Magarshak O.O.¹, Shmitko A.D.¹, Vlukachev I.V.¹, Vasileva G.V.¹, Blagovidov D.A.¹, Chuchalin A.G.², Avdeev S.N.², Karchevskaya N.A.²
Affiliations:
1. Mechnikov Research Institute of Vaccines and Sera
2. Research Institute of Pulmonology
Issue: Vol 93, No 4 (2016)
Pages: 55-60
Section: ORIGINAL RESEARCHES
Submitted: 10.04.2019
Published: 28.08.2016
URL: https://microbiol.crie.ru/jour/article/view/70
DOI: https://doi.org/10.36233/0372-9311-2016-4-55-60
ID: 70

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

Aim. Determination of intensity of immunity against measles in patients on waiting-list for lung transplantation. Materials and methods. IgG levels against measles virus were studied in blood sera of 80 adult patients (mean age 35.8± 11.4 years) on waiting-list of lung transplantation, without history of this disease. Determination of IgG levels against measles virus was carried out by ELISA using a standard kit from «Vektor-Best» (VectoMeasles-IgG). Results. Protective level of IgG against measles virus (above 0.18 I U/ml) was registered in 83.3% of examined patients. Mean level of anti-measles antibodies was within protective values - 1.53 IU/ml (95% confidence interval 1.17 - 1.89). Medium level of anti-measles antibodies (1 - 5 IU/ml) was registered in most of the analyzed samples (55.2%). A positive correlation between values of antibodies and age of patients (r=0.43) was detected. Dependence between levels of antibodies and previously executed hormonal and cytostatic therapy was not detected. Conclusion. Patients on waiting-list of solid organ transplantation are a group of risk for development of severe course of measles infection, that dictates the necessity of execution of vaccination at short terms before or after registration on the waiting-list.

Keywords

vaccine-controlled infections, measles, lung transplantation, anti-measles antibodies, immune-competent patients

References

Костинов М.П., Шмитько А.Д., Бочарова И.И., Черданцев А.П., Сависько А.А., Полищук В.Б. Уровень IgG-антител к вирусу кори в пуповинной крови новорожденных с учетом возраста матерей. Эпидемиология и инфекционные болезни. 2014, 3: 30-34.
Семененко Т.А.,Русакова Е.В.,Щербаков А.Г., Гайдаренко А.Д,.,Готвянская Т.П., Евсеева Л.Ф. Состояние популяционного иммунитета в отношении управляемых инфекций (по материалам банка сывороток крови). Эпидемиология и инфекционные болезни. Актуальные вопросы. 2012, 6: 10-15.
Организация и проведение серологического мониторинга состояния коллективного иммунитета к инфекциям, управляемым средствами специфической профилактики (дифтерия, столбняк, коклюш, корь, краснуха, эпидемический паротит, полиомиелит, гепатит В). Методические указания. МУ 3.1.2943-11, 2011.
Сылка О.И., Харсеева Г.Г., Леонова И.А. Напряженность имунитета к вирусу кори у населения г. Ростова-на-Дону. Журн. фундаментальной медицины и биологии. 2013,1: 41-43.
Эсауленко Е.В, Перадзе Х.Д., Дмитриева М.И., Сухорук А.А. Клинико-эпидемиологическая характеристика кори у взрослых. Лечение и профилактика. 2012, 3 (4): 90-92.
Blumberg Е. A., Brozena S. С., Stutman Р. et al. Immbnogenicity of pneumococcal vaccine in heart transplant recipients. Clin. Infect. Dis. 2001, 32: 307-310.
Burroughs M., Moscona A. Immunization of pediatric solid organ transplant candidates and recipients. Clin. Infect. Dis. 2000, 30 (6): 857-869.
Centers for disease control and prevention. Increased Transmission and Outbreaks of Measles - European Region. MMWR. 2011, 6 (47): 1605-1610.
Chesi C., Gunter M., Huzly D. et al. Immunization of liver and renal transplant recipients: a seroepidemiological and sociodemographic survey. Transpl. Infect. Dis. 2009, 11 (6): 507-512.
Chow J., Golan Y. Vaccination of solid-organ transplantation candidates. Clin. Infect. Dis. 2009, 49(10): 1550-1556.
Danzinger-Isakov L., Kumar D. AST Infectious Diseases Community of Practice. Guidelines for vaccination of solid organ transplant candidates and recipients. Am. J. Transplant. 2009, 9 (Suppl 4): 258-262.
Gasink L. B., Wurcell A.G., Kotloff R.M. et al. Low prevalence of prior streptococcus pneumoniae vaccination among potential lung transplant candidates. Chest. 2006, 130 (1): 218-221.

Supplementary files

Supplementary Files

Action

1. JATS XML

Download

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register

CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

Full Text

Abstract

Keywords

About the authors

References

Supplementary files

This website uses cookies