CONDITION OF ANTI-MEASLES IMMUNITY IN PATIENTS ON WAITING-LIST FOR LUNG TRANSPLANTATION

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Abstract

Aim. Determination of intensity of immunity against measles in patients on waiting-list for lung transplantation. Materials and methods. IgG levels against measles virus were studied in blood sera of 80 adult patients (mean age 35.8± 11.4 years) on waiting-list of lung transplantation, without history of this disease. Determination of IgG levels against measles virus was carried out by ELISA using a standard kit from «Vektor-Best» (VectoMeasles-IgG). Results. Protective level of IgG against measles virus (above 0.18 I U/ml) was registered in 83.3% of examined patients. Mean level of anti-measles antibodies was within protective values - 1.53 IU/ml (95% confidence interval 1.17 - 1.89). Medium level of anti-measles antibodies (1 - 5 IU/ml) was registered in most of the analyzed samples (55.2%). A positive correlation between values of antibodies and age of patients (r=0.43) was detected. Dependence between levels of antibodies and previously executed hormonal and cytostatic therapy was not detected. Conclusion. Patients on waiting-list of solid organ transplantation are a group of risk for development of severe course of measles infection, that dictates the necessity of execution of vaccination at short terms before or after registration on the waiting-list.

About the authors

V. B. Polischuk

Mechnikov Research Institute of Vaccines and Sera

Author for correspondence.
Russian Federation

A. A. Ryzhov

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

M. P. Kostinov

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

O. O. Magarshak

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

A. D. Shmitko

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

I. V. Vlukachev

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

G. V. Vasileva

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

D. A. Blagovidov

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

A. G. Chuchalin

Research Institute of Pulmonology

Russian Federation

S. N. Avdeev

Research Institute of Pulmonology

Russian Federation

N. A. Karchevskaya

Research Institute of Pulmonology

Russian Federation

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Copyright (c) 2016 Polischuk V.B., Ryzhov A.A., Kostinov M.P., Magarshak O.O., Shmitko A.D., Vlukachev I.V., Vasileva G.V., Blagovidov D.A., Chuchalin A.G., Avdeev S.N., Karchevskaya N.A.

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