BACTERIAL LYSATES OF ESCHERICHIA COLI STIMULATE PRODUCTION OF DEFENSINS BY PERIPHERAL BLOOD NEUTROPHILS

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Abstract

Aim. Study effect of a microbial-origin preparation based on Escherichia coli bacteria lysate (Uro-Vaksom) on defensin production (HNP1-3, lactoferrin - LF) and IgM/IgA in patients with recurring infections oflower urinary tract (RILUT). Materials and methods. 40 women with RILUT aged 18 - 68 years, who received monotherapy with Uro-Vaksom (bacterial lysate of 18 E. coli strains), and 26 healthy women were included into the study. Levels of defensins and immunoglobulins in blood were determined using ELISA (HNP1-3, LF, Elisa Kit, Hycult biotech, Netherlands; Serazym Human IgA, IgM, Germany). Rerate. A reduced level of defensins HNP1-3 and LF was noted in patients with RILUT, that gives evidence on chronical course of the inflammatory process on the organism. Use of E. coli lysate resulted in normalization of these parameters in blood sera of women. IgM and IgA levels in blood of the patients remained within normal values, and use of the bacterial lysate did not affect them. Conclusion. Use of Uro-Vaksom based on E. coli bacteria lysate has immune-correcting effect during therapy of patients with RILUT.

About the authors

N. K. Akhmatova

Mechnikov Research Institute of Vaccines and Sera

Author for correspondence.
Russian Federation

V. G. Khomenkov

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

E. V. Volkova

Research Institute of Urology and Intervention Radiology

Russian Federation

E. A. Akhmatova

Mechnikov Research Institute of Vaccines and Sera; Sechenov First Moscow State Medical University

Russian Federation

I. A. Semochkin

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

T. S. Perepanova

Research Institute of Urology and Intervention Radiology

Russian Federation

V. V. Zverev

Mechnikov Research Institute of Vaccines and Sera; Sechenov First Moscow State Medical University

Russian Federation

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Copyright (c) 2016 Akhmatova N.K., Khomenkov V.G., Volkova E.V., Akhmatova E.A., Semochkin I.A., Perepanova T.S., Zverev V.V.

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