BACTERIAL LYSATES OF ESCHERICHIA COLI STIMULATE PRODUCTION OF DEFENSINS BY PERIPHERAL BLOOD NEUTROPHILS

N. K. Akhmatova; Ахматова Н. К.; V. G. Khomenkov; Хоменков В. Г.; E. V. Volkova; Волкова Е. В.; E. A. Akhmatova; Ахматова Э. А.; I. A. Semochkin; Семочкин И. А.; T. S. Perepanova; Перепанова Т. С.; V. V. Zverev; Зверев В. В.

doi:10.36233/0372-9311-2016-4-50-55

BACTERIAL LYSATES OF ESCHERICHIA COLI STIMULATE PRODUCTION OF DEFENSINS BY PERIPHERAL BLOOD NEUTROPHILS

Authors: Akhmatova N.K.¹, Khomenkov V.G.¹, Volkova E.V.², Akhmatova E.A.¹^,3, Semochkin I.A.¹, Perepanova T.S.², Zverev V.V.¹^,3
Affiliations:
1. Mechnikov Research Institute of Vaccines and Sera
2. Research Institute of Urology and Intervention Radiology
3. Sechenov First Moscow State Medical University
Issue: Vol 93, No 4 (2016)
Pages: 50-55
Section: ORIGINAL RESEARCHES
URL: https://microbiol.crie.ru/jour/article/view/69
DOI: https://doi.org/10.36233/0372-9311-2016-4-50-55
ID: 69

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Abstract

Aim. Study effect of a microbial-origin preparation based on Escherichia coli bacteria lysate (Uro-Vaksom) on defensin production (HNP1-3, lactoferrin - LF) and IgM/IgA in patients with recurring infections oflower urinary tract (RILUT). Materials and methods. 40 women with RILUT aged 18 - 68 years, who received monotherapy with Uro-Vaksom (bacterial lysate of 18 E. coli strains), and 26 healthy women were included into the study. Levels of defensins and immunoglobulins in blood were determined using ELISA (HNP1-3, LF, Elisa Kit, Hycult biotech, Netherlands; Serazym Human IgA, IgM, Germany). Rerate. A reduced level of defensins HNP1-3 and LF was noted in patients with RILUT, that gives evidence on chronical course of the inflammatory process on the organism. Use of E. coli lysate resulted in normalization of these parameters in blood sera of women. IgM and IgA levels in blood of the patients remained within normal values, and use of the bacterial lysate did not affect them. Conclusion. Use of Uro-Vaksom based on E. coli bacteria lysate has immune-correcting effect during therapy of patients with RILUT.

Keywords

HNP1-3, recurring infection oflower urinary tract, Escherichia coli lysate, HNP1-3, lactoferrin, immunoglobulins

References

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BACTERIAL LYSATES OF ESCHERICHIA COLI STIMULATE PRODUCTION OF DEFENSINS BY PERIPHERAL BLOOD NEUTROPHILS

Full Text

Abstract

Keywords

About the authors

N. K. Akhmatova

V. G. Khomenkov

E. V. Volkova

E. A. Akhmatova

I. A. Semochkin

T. S. Perepanova

V. V. Zverev

References

Supplementary files

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