EFFECT OF EXOPOLISACCHARIDES OF LACTIC ACID BACTERIA ON THE SYNTHESIS OF PROINFLAMMATORY CYTOKINES BY MACROPHAGIC MICE IN PHAGOCYTOSIS OF STAPHYLOCOCCUS AUREUS

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Abstract

Aim. Study of the effect of exopolysaccharides (EPS) of lactic acid cocci on cytokine activity of macrophages of mice with phagocytosis in vitro Staphylococcus aureus 209-P. Materials and methods. The EPS of Streptococcus thermophilus and Lactococcus lactis B-1662 was used in the work. At 13, 5 and 7, AMP and PMP were isolated and the phagocytosis process was modeled in vitro. After 30 minutes, 1, 6 and 24 hours, the content of pro-inflammatory cytokines IL-1a and TNF-a was determined. Results. EPSs had an ambiguous effect on the production of cytokines. The greatest effect on the synthesis was provided by EPS of S. thermophilus. Conclusion. The results of the study allow us to talk about the possibility of using EPS of S. thermophilus as a preventive immunomodulator for correction of the cytokine status of animals.

About the authors

G. T. Uryadova

Vavilov State Agrarian University

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

E. A. Gorelnikova

Vavilov State Agrarian University

Email: noemail@neicon.ru
Russian Federation

N. A. Fokina

Vavilov State Agrarian University

Email: noemail@neicon.ru
Russian Federation

A. S. Dolmashkina

Vavilov State Agrarian University

Email: noemail@neicon.ru
Russian Federation

L. V. Karpunina

Vavilov State Agrarian University

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2018 Uryadova G.T., Gorelnikova E.A., Fokina N.A., Dolmashkina A.S., Karpunina L.V.

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