PATOGENEZ DISBAKTERIOZA KIShEChNIKA

Aim. Study mechanism of the development of intestine dysbiosis on the experimental model of
mice from the position of reinforcement of translocation of opportunistic Gram negative enterobacteria
(OGNE) from the intestine lumen into the system blood flow and the possibility of its
correction by lactoglobulin preparations. Materials and methods. Experimental medicinal dysbacteriosis
of the intestine was reproduced in mice by using gentamycin. Changes of immunologic
parameters in the animals during translocation of Gram negative enterobacteria and their LPS
from the intestine lumen into system blood flow were studied. Results. During intestine dysbioses
a pronounced inflammatory reaction was shown to develop at a local level with the increase of the
amount of proinflammatory cytokines with the sequence IL-1ƒ - IFNƒ - IL-6 and reinforcement
of formation of anti-endotoxin antibodies. Changes in the parameters of allergization of macroorganism
under the influence of LPS occurred synchronously with the increase of amount of (OGNE)
including escherichia with altered lactase activity in the background of its translocation into extrinsic
biotopes. In decompensated variant of dysbiosis a pronounced activation of immune reactive
spleen cells was noted. Immunobiologic preparations (lactoglobulin and low molecular
peptides of immune colostrum) administered to the animals in parallel with the antibiotic caused
deintoxication and desensitizing effect and reduced the side effect of its action. Conclusion. A
scheme of development of dysbiotic disorders in the intestine from the position of reinforcement
of translocation of (OGNE) from the intestine lumen into the system blood flow is proposed and
mechanisms of positive effect of lactoglobulin preparations and low molecular peptides of immune
colostrum that are perspective for the correction of this state are explained.

intestine dysbiosis, antibodies, endotoxin, dysbiosis correction