MECHANISMS OF RESISTANCE OF ENTEROCOCCI TO ANTIMICROBIAL PROTEINS AND PEPTIDES


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Abstract

Mechanisms of resistance of bacteria genus Enterococcus to the most important factors of innate immunity
of the host - antimicrobial proteins and peptides - are described in the review. Data on enterococci
lysozyme resistance associated with modification of peptidoglycan and changes in the net charge of the
bacterial cell surface are presented. The role of enterococci ƒ-factor with extra cytoplasmic SigV function is
described. Evidence on microbial activation/degradation of neutrophil ƒ-defensin (HNP-1), antibacterial
peptide LL-37, cecropin, ƒ-lysine (thrombocytic cationic peptide) is presented. The accumulated experimental
material is discussed from the position of persistence of enterococci - both pathogens causing various
infectious processes and commensals composing a part of normal host microflora.

About the authors

O V Bukharin

A V Valyshev

References

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