Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology14225ArticlesСтатьиMECHANISMS OF RESISTANCE OF ENTEROCOCCI TO ANTIMICROBIAL PROTEINS AND PEPTIDESМЕХАНИЗМЫ УСТОЙЧИВОСТИ ЭНТЕРОКОККОВ К АНТИМИКРОБНЫМ БЕЛКАМ И ПЕПТИДАМBukharinO VБухаринО В

Институт клеточного и внутриклеточного симбиоза, Оренбург

ValyshevA VВалышевА В

Институт клеточного и внутриклеточного симбиоза, Оренбург

Институт клеточного и внутриклеточного симбиоза, Оренбург151020122012895NO5 (2012)899413062023Received:13062023Published:15102012Copyright ©; 2012, Bukharin O.V., Valyshev A.V.Copyright ©; 2012, Бухарин О.В., Валышев А.В.2012Bukharin O.V., Valyshev A.V.Бухарин О.В., Валышев А.В.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/14225

Mechanisms of resistance of bacteria genus Enterococcus to the most important factors of innate immunity of the host - antimicrobial proteins and peptides - are described in the review. Data on enterococci lysozyme resistance associated with modification of peptidoglycan and changes in the net charge of the bacterial cell surface are presented. The role of enterococci ƒ-factor with extra cytoplasmic SigV function is described. Evidence on microbial activation/degradation of neutrophil ƒ-defensin (HNP-1), antibacterial peptide LL-37, cecropin, ƒ-lysine (thrombocytic cationic peptide) is presented. The accumulated experimental material is discussed from the position of persistence of enterococci - both pathogens causing various infectious processes and commensals composing a part of normal host microflora.

В обзоре описаны механизмы устойчивости бактерий рода Enterococcus к важнейшим факторам врожденного иммунитета хозяина - антимикробным белкам и пептидам. Представлены данные о лизоцимрезистентности энтерококков, связанной с модификацией пептидогликана и изменением сетевого заряда поверхности бактериальной клетки. Описана роль энтерококкового ƒ-фактора с экстрацитоплазматической функцией SigV. Приводятся свидетельства микробной инактивации/деградации ƒ-дефенсина нейтрофилов (HNP-1), антибактериального пептида LL-37, цекропина, ƒ-лизина (тромбоцитарного катионного белка). Накопленный экспериментальный материал обсуждается с позиции персистенции энтерококков - как патогенов, вызывающих различные инфекционные процессы, так и комменсалов, составляющих часть нормальной микрофлоры хозяина.

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