INTESTINE INFECTIONS, INFLAMMATION AND AUTOIMMUNITY. TRIGGER AND EFFECTOR MECHANISMS OF AUTOIMMUNE DISEASE DEVELOPMENT AS AN OUTCOME OF INTESTINE INFECTIONS


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Abstract

Problem of interconnection of intestine infections, inflammatory intestine diseases and autoimmune illnesses in this article is examined from the position of their trigger and effector mechanisms. Among trigger mechanisms special attention is given to mechanisms by which the presence of pathogenic microbial causative agent in the organism is transformed into an autoimmune process. The phenomenon of antigen mimicry, carriage of superantigens by pathogenic agents, the role ofcell apoptosis are accentuated. Autoimmune diseases are examined in the same way as genetically determined phenomenon with designation of main genes, polymorphism of which is involved in the development of this pathology. Among effector reactions accompanying the development of autoimmune process against the background of intestine infections the role of B1 lymphocytes, Th17 and Th1 are analyzed in more detail. Special attention is given to pathogenetic and protective role of natural killers which is recognized as relatively understudied.

About the authors

I. P Balmasova

Russian University of Peoples’ Friendship, Moscow, Russia

R. I Sepiashvili

Russian University of Peoples’ Friendship, Moscow, Russia

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