Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13856ArticlesСтатьиReview ArticleINTESTINE INFECTIONS, INFLAMMATION AND AUTOIMMUNITY. TRIGGER AND EFFECTOR MECHANISMS OF AUTOIMMUNE DISEASE DEVELOPMENT AS AN OUTCOME OF INTESTINE INFECTIONSКИШЕЧНЫЕ ИНФЕКЦИИ, ВОСПАЛЕНИЕ И АУТОИММУНИТЕТ. ПУСКОВЫЕ И ЭФФЕКТОРНЫЕ МЕХАНИЗМЫ РАЗВИТИЯ АУТОИММУННЫХ ЗАБОЛЕВАНИЙ КАК ИСХОДА КИШЕЧНЫХ ИНФЕКЦИЙBalmasovaI. PБалмасоваИ. ПSepiashviliR. IСепиашвилиР. ИRussian University of Peoples’ Friendship, Moscow, RussiaРоссийский университет дружбы народов, Москва150420132013902NO2 (2013)№2 (2013)10211109062023Received:09062023Published:15042013Copyright ©; 2013, Balmasova I.P., Sepiashvili R.I.Copyright ©; 2013, Балмасова И.П., Сепиашвили Р.И.2013Balmasova I.P., Sepiashvili R.I.Балмасова И.П., Сепиашвили Р.И.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13856

Problem of interconnection of intestine infections, inflammatory intestine diseases and autoimmune illnesses in this article is examined from the position of their trigger and effector mechanisms. Among trigger mechanisms special attention is given to mechanisms by which the presence of pathogenic microbial causative agent in the organism is transformed into an autoimmune process. The phenomenon of antigen mimicry, carriage of superantigens by pathogenic agents, the role ofcell apoptosis are accentuated. Autoimmune diseases are examined in the same way as genetically determined phenomenon with designation of main genes, polymorphism of which is involved in the development of this pathology. Among effector reactions accompanying the development of autoimmune process against the background of intestine infections the role of B1 lymphocytes, Th17 and Th1 are analyzed in more detail. Special attention is given to pathogenetic and protective role of natural killers which is recognized as relatively understudied.

Проблема взаимосвязи кишечных инфекций, воспалительных заболеваний кишечника и аутоиммунных болезней в данной статье рассматривается с позиций их пусковых и эффекторных механизмов. Среди пусковых механизмов особое внимание уделяется механизмам, с помощью которых наличие патогенного микробного возбудителя в организме трансформируется в аутоиммунный процесс. Основной акцент делается на явлении антигенной мимикрии, носительстве патогенными агентами суперантигенов, роли клеточного апоптоза. Аутоиммунные заболевания рассматриваются также как генетически обусловленный феномен с указанием основных генов, полиморфизм которых причастен к развитию данной патологии. Среди эффекторных реакций, сопутствующих развитию аутоиммунного процесса на фоне кишечных инфекций, более детально анализируется роль В1лимфоцитов, Th17 и Th1. Особое внимание уделяется патогенетической и про-тективной роли естественных киллеров, которая признается относительно малоизученной.

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