ROLE OF NEUTROPHIL EXTRACELLULAR TRAPS IN ESPECIALLY DANGEROUS BACTERIAL INFECTIONS

Cover Page


Cite item

Full Text

Abstract

Novel data on neutrophil extracellular traps (NET), carrying out capture and killing of pathogenic microorganisms with higher effectiveness than during phagocytosis, are presented. A contemporary view on how neutrophils choose intracellular (phagocytosis) or extracellular (NETosis) mechanism of bactericidity during interaction with pathogenic microorganisms is given. Experimental data on the presence in causative agents of plague, cholera and melioidosis of mechanisms of protection from bactericidal effect of NET, as well as NET’S role in regulation of immune response and sepsis development are analyzed.

About the authors

A. L. Kravtsov

Russian Research Institute of Plague Control «Microbe»

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

References

  1. Богачева Н. В., Крючков А.В.,ДармовИ.В., Воробьев К. А., Печенкин Д. В., Елагин Г. Д. Колесников Д.П. Экспериментальная оценка методом проточной цитофлуориметрии уровня клеточной иммунологической памяти у лиц, вакцинированных против чумы и сибирской язвы. Клин. лаб. диагностика. 2013, 11: 48-53.
  2. Воробьева Н.В., Пинегин Б.В. Нейтрофильные внеклеточные ловушки: механизмы образования, роль в норме и при патологии. Биохимия. 2014, 79 (12): 1580-91.
  3. Долгушин И.И., Савочкина А.Ю., Курносенко И.В., Долгушина В.Ф., Савельев А.А. Самусева И.В., Майкова В.Б. Участие внеклеточных нейтрофильных ловушек в защитных и патологических реакциях организма. Российский иммунологический журнал. 2015, 9 (18), 2: 164-170.
  4. Киселева Е.П. Новые представления о противоинфекционном иммунитете. Инфекция и иммунитет. 2011, 1:9-14.
  5. Кравцов А.Л., Шмелькова Т.П., Щуковская Т.Н. Влияние противочумной вакшошаа на функциональную активность клеток врожденного иммунитета человека. Прос.-особо опасных инф. 2011, 1 (107): 77-80.
  6. Кравцов А.Л. Формирование внеклеточных ловушек - эффективный механизм защиты от патогена. Пробл. особо опасных инф. 2012, 2 (112): 69-74.
  7. Кутырев В.В., Коннов Н.П., Волков Ю.П. Возбудитель чумы: ультраструктура и локализация в переносчике. М., Медицина, 2007.
  8. Нестерова И.В., Колесникова Н.В., Чудилова Г.А., Ломтатидзе Л.В., Ковалева С.В., Евглевский А.А. Нейтрофильные гранулоциты: новый взгляд на «старых игроков» на иммунологическом поле. Иммунология. 2015, 4: 257-65.
  9. Семенов Б.Ф., Зверев В.В. Концепция быстрой иммунологической защиты от патогенов. Журн. микробиол. 2007, 4: 93-100.
  10. Фрадкин В.А. Диагностика аллергии реакциями нейтрофилов крови. М., Медицина, 1985.
  11. Beiter К., Wartha Е, Albiger В. et al. An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr. Biolology. 2006, 16: 401-407.
  12. Branzk N., Lubojemska A., Hardison S.E. et al. Neutrophil sense microbial size and selectively release neutrophil extracellular traps in response to large pathogens. Nat. Immunol. 2014, 15 (11): 1017-1025.
  13. Brinkmann V., Reichard U., Goosmann C. et al. Neutrophil extracellular traps kill bacteria. Science. 2004, 303: 1532-1535.
  14. Camicia G., Pozner R., Larranaga G. Neutrophil extracellular traps in sepsis. Shock. 2014,42 (4): 286-294.
  15. Casutt-Mayer S., Renzi E, Schmaler M. et al. Oligomeric coiled-coil adhesin YadA is a double-edged sword. PLoS ONE. 2010, 5 (12): e 15159. doi: 10.1371/journal. pone. 0015159.
  16. Chen G., Zhang D., Fuchs T.A. et al. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood. 2014, doi: 10.1182/blood-2013-10-529982.
  17. Clark S.R., Ma A.C., Tavener S.A. et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 2007, 13: 463-469.
  18. Davey H.M., Kell D.B. Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analysis. Microbiol. Rev. 1996, 60: 641-696.
  19. de Jong H.K., Koh G., Achouiti A. et al. Neutrophil extracellular traps in the host defense against sepsis induced Burkholderia pseudomallei (melioidosis). Intensive Care Medicine Experimental. 2014, 2 (21). doi: 10.1186/s40635-014-0021-2.
  20. Domenech M., Ramos-Sevillano E., Garcia E. et al. Biofilm formation avoids complements immunity and phagocytosis of Streptococcus pneumoniae. Infect. Immun. 2013, 81: 2606-2615.
  21. Eisele N.A., Lee-Lewis H., Besch-Williford C. et al. Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in murine model of pneumonic plague. Am. J. Pathol. 2011, 178 (3): 1190-1200.
  22. Fuchs T.A., Abed U., Goosmann C. et al. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 2007, 176: 231-241.
  23. Fuchs T.A., Brill A., Duerschmied D. et al. Extracellular DNA traps promote thrombosis. PNAS. 2010, 107 (36): www.pnas.org/cgi/doi/10.1073/pnas. 1005743107.
  24. Gupta A.K., Joshi M.B., Phillippova M. et al. Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death. FEBS Lett. 2010, 584: 3193-3197.
  25. Hickey M.J., Kubes P. Intravascular immunity: the host-pathogen encounter in blood vessels. Nat. Rev. Immunology. 2009, 9: 364-375.
  26. Kravtsov A.L., Bobyleva E.V., Grebenyukova T.P., Kuznetsov O.S., Kulyash Y.V. Flow micro-fluorometric analysis of phagocyte degranulation in bacteria infected whole human blood cell cultures. Proc. SPIE. 2002, 4707: 395-402.
  27. Landoni V.I., Chiarella R, Martire-Greco D. et al. Tolerance to lipopolysaccharide promotes an enhanced neutrophil extracellular trap formation leading to a more efficient bacterial clearance in mice. Clin, and Exper. Immunol. 2012, 168: 153-163.
  28. Ma C.A., Kubes P.K. Platelets, neutrophils, and neutrophil extracellular traps in sepsis. J. Thromb. Haemostasis. 2008, 6 (3): 415-420.
  29. Marcos V., Zhou Z., Yildirim A. et al. CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airways inflammation. Nat. Med. 2010, 16: 1018-1023.
  30. Mayer-School A., Hurwitz R., Brinkmann V. et al. Human neutrophils kill Bacillus anthracis. PLos Pathog. 2005, 1 (3): e23. doi: 10.1371/joumal. ppat. 0010023.
  31. McAdow M., Kim H.A., DeDent A.C.etal. Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog. 2011,7 (10): e 1002307. doi: 10.1371/ jounal. ppat: 1002307.
  32. McDonald B., Urrutia R., Yipp B.G. et al. Intravascular neutrophil extracellular traps capture bacteria from bloodstream during sepsis. Cell Host Microbe. 2012, 12 (3): 324-333.
  33. Murphey E.D., Fang G., Varma T.K., Sherwood E.R. Improved bacterial clearance end decreased mortality can be induced by LPS tolerance and is not dependent upon IFN-gamma. Shock. 2007, 27: 289-295.
  34. Papayannopoulos V, Metzier K.D., Hakkim A., Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J. Cell Biol. 2010, 191: 677-691.
  35. Prashar A., Bhatia S., Gigliozzi D. et al. Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages. J. Cell Biol. 2013, 203: 1081-1097.
  36. Riyara D., Buddhisa S., Korbsrisate S. et al. Neutrophil extracellular traps exhibit antibacterial activity against Burkholderia pseudomallei and are influenced by bacterial and host factors. Infec.Immun. 2012, 80 (11): 3921-3929.
  37. Seper A., Hosseinzadeh A., Gorkiewicz G. et al. Vibrio cholerae evades neutrophil extracellular traps by the activity of two extracellular nucleases. PLoS Pathog. 2013, 9 (9): el003614. doi: 10.1371/journal, ppat.1003614.
  38. Seper A., Fengler V.H., Roier S. et al. Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation. Mol. Microbiol. 2011, 82: 1015-1037.
  39. Shannon J.G., Hasenkrug A.M., Dorward D.W. et al. Yersinia pestis subverts the dermal neutrophil response in mouse model of bubonic plague. mBio. 2013,4(5): eOO 170-13. doi: 10.1128/ mBio. 00170-13.
  40. Silva T.M. Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism. J. Leuk. Biology. 2010, 88 (5): 885-896.
  41. Simpson A.J. Melioidosis: a clinical model for gram-negative sepsis. J. Med. Microbiology. 2001,50 (8): 657-658.
  42. Tanaka K., Koike Y., ShimuraT. etal. In vivo characterization of neutrophil extracellular traps in various organs of a murine sepsis model. PLoS One. 2014, 9 (11): ell 1888. doi: 10.1371/ journal, pone.0111888.
  43. Tang A.H., Brunn G.J., Cascalho M., Platt J.L. Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. J. Leuk. Biology. 2007, 82: 282-285.
  44. Tillack K., Breiden R, Martin R., Sospedra M. T-lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses. J. Immunology. 2012, 188 (7): 3150-3159.
  45. Weinrauch Y., Drujan D., Shapiro S.D. et al. Neutrophil elastase targets virulence factors of enterobacteria. Nature. 2002, 417: 91-94.
  46. Yoong P., Cywes-Bentley C., Pier G.B. Poly-N-Acetylglucosamine expression by wild-type Yersinia pestis is maximal at mammalian, not flea, temperatures. mBio. 2012,3(4). E00217-12. doi: 10.1128/mBio.00217-12.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Kravtsov A.L.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС77-75442 от 01.04.2019 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies