Email this article A CASE OF IMPORT OF GENOTYPE 4 HEPATITIS E VIRUS INTO RUSSIA
- Authors: Mikhailov M.I.1, Malinnikova E.Y.1,2, Kyuregyan K.K.1, Isaeva O.V.1
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Affiliations:
- Chumakov Institute of Poliomyelitis and Viral Encephalites
- Russian Medical Academy of Post-Graduate Education
- Issue: Vol 93, No 3 (2016)
- Pages: 64-69
- Section: ORIGINAL RESEARCHES
- Submitted: 10.04.2019
- Published: 28.06.2016
- URL: https://microbiol.crie.ru/jour/article/view/51
- DOI: https://doi.org/10.36233/0372-9311-2016-3-64-69
- ID: 51
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Abstract
Aim. Description of the first documented case of imported hepatitis E, associated with genotype 4 of HEV and introduced from southern France. Materials and methods. Clinical, epidemiologic and laboratory analysis of the imported case of disease of hepatitis E was carried out. Phylogenetic analysis of nucleotide sequences of HEV isolate, taken from the patient, was carried out. Results. Epidemiologic analysis allowed to assume imported character of the detected case of HEV-infection. Comparative analysis of nucleotide sequences of regions of the open reading frame 2 (300 nt) and open reading frame 1 (721 nt) of HEV genome, isolated from the patient, showed identity of this isolate with variants of genotype 4 HEV, isolated in France in 2009 - 2011 from patients with autochthonous hepatitis E. Conclusion. The results obtained confirm the case of import into Russia of genotype 4 HEV from south-eastern France (Corsica), where spread of this virus genotype is observed in recent years.
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About the authors
M. I. Mikhailov
Chumakov Institute of Poliomyelitis and Viral Encephalites
Author for correspondence.
Email: noemail@neicon.ru
Россия
E. Yu. Malinnikova
Chumakov Institute of Poliomyelitis and Viral Encephalites; Russian Medical Academy of Post-Graduate Education
Email: noemail@neicon.ru
Россия
K. K. Kyuregyan
Chumakov Institute of Poliomyelitis and Viral Encephalites
Email: noemail@neicon.ru
Россия
O. V. Isaeva
Chumakov Institute of Poliomyelitis and Viral Encephalites
Email: noemail@neicon.ru
Россия
References
- Быстрова Т. Н., Полянина А. В., Княгина О. Н. Качественные и количественные параметры эпидемического процесса гепатит Е-инфекции на территории Среднеевропейского региона России. Мир вирусных гепатитов. 2010, 1: 9-13.
- Михайлов М.И., Шахгильдян И.В., Онищенко Г.Г. Энтеральные вирусные гепатиты (этиология, эпидемиология, диагностика, профилактика). М., ВУНМЦ Росздрава, 2007.
- Colson Р, Swiader L., Motte A. et al. Circulation of almost genetically identical hepatitis E virus of genotype 4 in France. J. Clin. Virol. 2012, 55 (2): 181-183.
- Colson R, Romanet P, MoalV. et al. Autochthonous infections with hepatitis E virus genotype 4, France. Emerg. Infect. Dis. 2012, 18 (8): 1361-1364.
- Colson R, Borentain R, Queyriaux B. et al. Pig liver sausage as a source of hepatitis E virus transmission to humans. J. Infect. Dis. 2010, 202 (6): 825-834.
- Emerson S.U., Purcell R.H. Hepatitis E virus. Rev. Med. Virol. 2003, 13: 145-154.
- Geng J.B., Wang M.R., Wang L. et al. Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China.World J. Gastroenterol. 2012, 18: 965-970.
- Hakze-van der Honing R.W. et al. First isolation of hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium. PLoS One. 2011, 6 (8): e22673.
- Izopet J., Labrique A.B., Basnyat B. et al. Hepatitis E virus seroprevalence in three hyperendemic areas: Nepal, Bangladesh and southwest France. J. Clin. Virol. 2015, 70: 39-42.
- Khuroo M.S. Discovery of hepatitis E: the epidemic non-A, non-B hepatitis 30 years down the memory lane. Virus Res. 2011, 161 (1): 3-14.
- Lewis H.C., Wichmann O., Duizer E. Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review. Epidemiol. Infect. 2010, 138: 145-166.
- Lu L., Li C., Hagedom C.H. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev. Med. Virol. 2006,16 (1): 5-36.
- Wichmann O., Schimanski S., Koch J. et al. Phylogenetic and case-control study on hepatitis E virus infection in Germany. J. Infect. Dis. 2008,198 (12): 1732-1741.
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