BIOFILMS OF PATHOGENIC BURKHOLDERIA AND THEIR ROLE IN RESISTANCE TO ANTIBIOTICS

Cover Page


Cite item

Full Text

Abstract

The review contains the current knowledge on the main issues of Burkholderia pseudomallei and Burkholderia mallei biofilm formation. The role ofknown structural elements of Burkholderia cells (flagella, type IV pili, LPS), as well as autotransporter adhesin proteins in the attachment of bacteria to surfaces, the formation of microcolonies and biofilm is described. The review also includes information of genetic regulatory mechanisms (QS-systems, RpoE-sigma factor, c-di-GMP, two-component signal transduction system), differentially expressed genes related to the formation of B. pseudomallei biofilm, role ofbiofilms in the virulence and resistance to antibiotics of pathogenic Burkholderia and their significance for the chronic processes and recurrent course of melioidosis and glanders.

About the authors

E. V. Shubnikova

Volgograd Research Institute for Plague Control

Author for correspondence.
Email: noemail@neicon.ru
Россия

L. K. Merinova

Volgograd Research Institute for Plague Control

Email: noemail@neicon.ru
Россия

T. V. Senina

Volgograd Research Institute for Plague Control

Email: noemail@neicon.ru
Россия

E. V. Korol

Volgograd Research Institute for Plague Control

Email: noemail@neicon.ru
Россия

O. A. Merinova

Volgograd Research Institute for Plague Control

Email: noemail@neicon.ru
Россия

References

  1. Гинцбург А.Л., Ильина Т.С., Романова Ю.М. «Quorum sensing» или социальное поведение бактерий. Журн. микробиол. 2003, 5: 86-93.
  2. Евдокимова Н.В., Черненькая Т.В. Персистирующие клетки микроорганизмов - новый взгляд на старую проблему. Клин, микробиол. антимикроб, химиотер. 2013,15 (3): 192197.
  3. Романова Ю.М., Гинцбург А.Л. Бактериальные биопленки как естественная форма существования бактерий в окружающей среде и организме хозяина. Журн. микробиол. 2011,3:99-109.
  4. Balder R., Lipski S., Lazarus J.J. et al. Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells. BMC Microbiology. 2010, 10: 250.
  5. Bandeira T., Moreira C.A, Brilhante R.S. et al. In vitro activities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole against biofilm of Brazilian strains of Burkholderia pseudomallei. Antimicrob. Agents Chemother. 2013,57 (11): 5771-5773.
  6. Castelo-Branco D.S., Riello G.B., Vasconcelos D.C. et al. Famesol increases the susceptibility of Burkholderia pseudomallei biofilm to antimicrobials used to treat melioidosis. J. Applied Microbiology. 2016, 120 (3): 600-606.
  7. Chan Y.Y., Chua K.L. The Burkholderia pseudomallei BpeAB-OprB efflux pump: expression and impact on quorum sensing and virulence. J. Bacteriol. 2005,187:4707-4719.
  8. Cheng A.C., Currie B.J. Melioidosis: epidemiology, pathophysiology, and management. Clin. Microbiol. 2005,18 (2): 383-416.
  9. Chin C.Y., Нага Y., Ghazali A.K. et al. Global transcriptional analysis of Burkholderia pseudomallei high and low biofilm producers reveals insights into biofilm production and virulence. BMC Genomics. 2015, 16 (1): 471.
  10. Costerton J.W., Stewart P.S., Greenberg E.P. Bacterial bofilms: a common cause ofpersistence infections. Science. 1999, 284 (5418): 1318-1322.
  11. Davey M.E, O’Toole G.A. Microbial biofilms: from ecology to molecular genetics. Microbiol. Molecul. Biol. 2000, 64 (4): 847-867.
  12. DeShazer D., Brett PJ., Carlyon R. et al. Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterization of the flagellin structural gene. J. Bacteriol. 1997, 179: 2116-2125.
  13. Diggle S.R, Lumjiaktase P., Dipilato F. et al. Functional genetic analysis 486 reveals a 2-Alkyl-4-quinolone signaling system in the human pathogen Burkholderia 487 pseudomallei and related bacteria. Chem Biol. 2006, 13: 701-710.
  14. Donlan R.M. Biofilms: Microbial life on surfaces. Emerg. Infect. Dis. 2002, 8 (9): 881-890.
  15. Duerkop B.A., Herman J.R, Ulrich R.L. et al. The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone. J. Bacteriol. 2008,190: 5137-5141.
  16. Duerkop B.A., Ulrich R.L., Greenberg E.P. Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaRl-Bmall quorum sensing. J. Bacteriol. 2007,189: 50345040.
  17. Essex-Lopresti A.E., Boddey J.A., Thomas R. et al. Atype ГУ pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo. Infect. Immun. 2005, 73 (2): 12601264.
  18. Galyov E.E., Brett P.J., De Shazer D. Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis. Annu. Rev. Microbiol. 2010, 64:495-517.
  19. Gamage A.M., Shui G., Wenk M.R. et al. N-Octanoylhomoserine lactone signalling mediated by the BpsI-BpsR quorum sensing system plays a major role in biofilm formation of Burkholderia pseudomallei. Microbiology. 2011,157: 1176-1186.
  20. HortonR.E., Grant G.D., MatthewsB. et al. Quorum sensing negatively regulates multinucleate cell formation during intracellular growth ofBurkholderia pseudomallei in macrophage-like cells. PLoS One. 2013, 8: e63394.
  21. Kamjumphol W., ChareoosudjaiS., ChareonsudjaiR et al. Enviroomental factorraffecting Burkholderia pseudomallei biofilm aormctinv. Southeast Asicv J. Trop. Med. Public Health. 2013,44(1): 72-81.
  22. Ксгс1сп E., Warnick P. Signals, regulatory networks, and materials that build and break bacterial biofilms. Microbiol. Mol. Biol. 2009,73 (2): 310-347.
  23. Kim H.S., Schell M.A., Yan Yu et cl. Bacterial genome adaptation to niches: Divergence of the potential virulence genes in three Burkholderia species of different survival strategies. BMC Genomics. 2005,6:174.
  24. Kiratisin P., Sanmee S. Roles and interactions of Burkholderic pseudomcll^ BpsIR quorumsensing system determinants. J. Bacteriol. 2008,190: 7291-7297.
  25. Korbsrisate S., Vanapom M., Kerdsuk P. et al. The Burkholderic pseudomcll^ RpoE (AlgU) operon is involved in environmental stress tolerance cnd biofilm formation. FEMS Microbiology Letters. 2005, 252: 243-249.
  26. Lczar Adler N.R., Dean R.E., Saint R.J. et al. Identification of a predicted trimeric cutotravs-porter adhesm requiredfor biofilm formation of Burkholderic pseudomcllei. PLoS One. 2013, 8(11): e79461.
  27. Lczar Adler N.R., Stevens J.M., Stevens M.P. et cl. Autotravsporter■s cnd their role in the virulence of Burkholderia pseudomi^i and Burkholderic mallei. Frontiers in Microbiology 2011,2:15.
  28. Lee H.S., Gu F., Ching S.M. et al. CdpA is c Burkholderim pseudomcllei cyclic di-GMP phos phodiesterase involved in autoaggregation, flagellum synthesis, motility, biofilm formation, cell invasion, cnd cytotoxicity. and Immunity. 2010, 78 (5): 1832-1840.
  29. Limmathurotsakul D., Pceyao A., Wongratanacheewm S. et cl. Role of Burk0nlderia pseu-dnmcllei biofilm aormatinn and lipopolysaccharide in relapse of melioidosis introduction. Clin. Microbiol. Infect. 2014, 20 (11): 0854-0856.
  30. Loscdc L., Rowing C.M., DeShazer D. et cl. Continuing evolution of Burkholderic mallei through genome reduction and large-scale rearrangements. Genome Biol. Evolution. 2010,2: 102-116.
  31. Maj'aeczyy C.D., Britinvahac M.J., Jacoos M.A. ee al. Crors-sphetet comphriron d fhh Burkholderim pseudomi^i, Burkholderic tOcilcndevsis, cnd Burkholderic mallei quorumsensing regulons. J. Bacteriol. 2014,196 (22): 3862-3871.
  32. Mongkolrob R., Taweechcisupcpong S., Tungpr^dcbk^l S. Correlation between biofilm production, antibiotic susceptibility and exopolysaccharide composition in Burkholderia pseudomallei bpsl, ppk, and rpoS mutant strains. Microbiology and Immunology. 2015, 59 (11): 653-663.
  33. Pibalpakdee P., Wongratanacheewin S., Taweechaisupapong S. et al. Diffusion and activity of antibiotics against Burkholderia pseudomallei biofilms. J. Antimicrob. Agents. 2012, 39 (4): 356-359.
  34. Plumley B.A., Martina К. H., Borleea G. I. et al. Thermoregulation of biofilm formation in Burkholderia pseudomallei is disrupted by mutation ofa putative diguanylate cyclase. J. Bacteriol. 2017, 199 (5): e00780-16.
  35. Puthuceary S.D. Melioidosis in Malaysia. Med. J. Malaysia. 2009, 64: 266-274.
  36. Sawasdidoln C., Taweechaisupapong S., Sermswan R.W. et al. Growing Burkholderia pseudomallei in biofilm stimulating conditions significantly induces antimicrobial resistance. PLoS One. 2010, 5(2): 1-10.
  37. SchweizerH.P. Mechanisms ofantibiotic resistance in Burkholderia pseudomallei: implications for treatment of melioidosis. Future Microbiol. 2012, 7: 1389-1399.
  38. Sidrim J. J., Vasconcelos D. C., Riello G. B. et al. Promethazine improves antibiotic efficacy and disrupts biofilms of Burkholderia pseudomallei. Biofouling. 2017, 33 (1): 88-97.
  39. Soto S.M. Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence. 2013,4: 223-229.
  40. Taweechaisupapong S., Kaewpa C., Arunyanart C. et al. Virulence of Burkholderia pseudomallei does not correlate with biofilm formation. Microb. Pathog. 2005, 39 (3): 77-85.
  41. TuunipoonsakS., Monggklrob R., KituddmsubK. etal. Role of Burkkolderiapseudomallei polyphosphate kinase in an oxidative stress response, motilities, and biofilm formation. J. Microbiol. 2010,48 (1): 63-70.
  42. Ulrich R.L., Deshazer D., Brueggemann E.E. et al. Role of quorum sensing in the pathogenicity of Burkholderra pseddbmallei. J. Med. Microbiol. 2004, 53:1053-1064.
  43. Ulrich R.L., Deshazer D., Hines H.B. et al. Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei. Infect. Immun. 2004, 72: 65896596.
  44. Valade E., Thibault F.M., Gauthier Y.P. et al. The Pmll-PmlR quorum-sensing system in Burkholdeuria psedomallei plays a key role in virulence and modulates production of the MprApootupse. J. Bacteriol. 200^4,186:2288-2294.
  45. Vial L., Lepine E, Milot S. et al. Burkholdeuria psedomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation. J. Bacteriol. 2008, 190: 5339-5352.
  46. Vorachit M., Lam K., Jayanetra P. et al. Electron microscopy study of the mode of growth of Pseudomonas psub0omallei in vitro and in vivo. J. Trap. Med. Hyg. U^<95,98: 379-391.
  47. Yuen C.W, Ong E.B., Mohamad S. et al. Construction and characterization of a Burkholdeuria psedomallei wzm deletion mutant. J. Microbiol. Biotechnot 2012, 22:1336-1342.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Shubnikova E.V., Merinova L.K., Senina T.V., Korol E.V., Merinova O.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС77-75442 от 01.04.2019 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies