Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology25410.36233/0372-9311-2018-1-101-111REVIEWSОБЗОРЫBIOFILMS OF PATHOGENIC BURKHOLDERIA AND THEIR ROLE IN RESISTANCE TO ANTIBIOTICSБИОПЛЕНКИ ПАТОГЕННЫХ БУРКХОЛЬДЕРИЙ И ИХ РОЛЬ В РЕЗИСТЕНТНОСТИ К АНТИБИОТИКАМShubnikovaE. V.ШубниковаЕ. В.
Russian Federation
MerinovaL. K.МериноваЛ. К.
Russian Federation
SeninaT. V.СенинаТ. В.
Russian Federation
KorolE. V.КорольЕ. В.
Russian Federation
MerinovaO. A.МериноваО. А.
Russian Federation
Volgograd Research Institute for Plague ControlВолгоградский научно-исследовательский противочумный институт2802201895110111110042019Copyright ©; 2018, Shubnikova E.V., Merinova L.K., Senina T.V., Korol E.V., Merinova O.A.Copyright ©; 2018, Шубникова Е.В., Меринова Л.К., Сенина Т.В., Король Е.В., Меринова О.А.2018Shubnikova E.V., Merinova L.K., Senina T.V., Korol E.V., Merinova O.A.Шубникова Е.В., Меринова Л.К., Сенина Т.В., Король Е.В., Меринова О.А.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/254

The review contains the current knowledge on the main issues of Burkholderia pseudomallei and Burkholderia mallei biofilm formation. The role ofknown structural elements of Burkholderia cells (flagella, type IV pili, LPS), as well as autotransporter adhesin proteins in the attachment of bacteria to surfaces, the formation of microcolonies and biofilm is described. The review also includes information of genetic regulatory mechanisms (QS-systems, RpoE-sigma factor, c-di-GMP, two-component signal transduction system), differentially expressed genes related to the formation of B. pseudomallei biofilm, role ofbiofilms in the virulence and resistance to antibiotics of pathogenic Burkholderia and their significance for the chronic processes and recurrent course of melioidosis and glanders.

Обзор содержит данные литературы, касающиеся основных вопросов образования биопленок возбудителями мелиоидоза и сапа (Burkholderia pseudomallei и Burkholderia mallei). Рассмотрена роль известных структурных элементов клеток буркхольдерий (жгутиков, пилей IV типа, ЛПС), а также белков-автотранспортеров адгезинов в прикреплении бактерий к поверхностям, формировании микроколоний и образовании биопленки. Представлены материалы исследования генетических регуляторных механизмов (QS-систем, RpoE-сигма фактора, c-di-GMP, двухкомпонентной системы трансдукции сигналов TCS) и данные о дифференциально экспрессирующихся генах, имеющих отношение к формированию биопленки В. pseudomallei. Приведены результаты изучения роли биопленок в вирулентности и резистентности к антибиотикам патогенных буркхольдерий и их значения в развитии хронических форм и рецидивирующего течения мелиоидоза и сапа.

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