Email this article COGNITIVE AXIS OF AGING: INFLAMMATION - MICROBIOTA OF SMALL INTESTINE
- Authors: Filippova Y.Y.1, Burnistrova A.L.1
-
Affiliations:
- Chelyabinsk State University
- Issue: Vol 94, No 5 (2017)
- Pages: 3-9
- Section: ORIGINAL RESEARCHES
- Submitted: 10.04.2019
- Published: 28.10.2017
- URL: https://microbiol.crie.ru/jour/article/view/189
- DOI: https://doi.org/10.36233/0372-9311-2017-5-3-9
- ID: 189
Cite item
Full Text
Abstract
Aim. Detect connection between cognitive dysfunction in senior people with systemic infection profile and small intestine microbiota structure. Materials and methods. 42 senior individuals were included into the study All the examined have been divided into 2 groups based on the results of psychic status: 20 individuals with moderate cognitive disorders - «active longevity» group and 22 individuals with pronounced cognitive deficiency - «mercy» group. Systemic inflammation status and structure and quantitative composition of microbiota of small intestine was determined in all the senior individuals using gas chromatography mass-spectrometry of microbial markers. Results. Interconnection between systemic level of cytokines and microbiota structure of small intestine in senior people with various cognitive status was determined. Significant correlations between levels of pro-inflammatory cytokine IL-6 in blood plasma and quantity of Propionibacterium jensenii, Moraxella spp., Bacillus cereus and Fusobacterium spp. in small intestine and the degree of cognitive failure were detected for the first time. Conclusion. The parameters obtained could be used as predictive biomarkers of cognitive dysfunction in senior people.
About the authors
Yu. Yu. Filippova
Chelyabinsk State University
Author for correspondence.
Email: noemail@neicon.ru
Россия
A. L. Burnistrova
Chelyabinsk State University
Email: noemail@neicon.ru
Россия
References
- Бурмистрова А. Л., Филиппова Ю.Ю., Михайлова А.С. Нейро-иммуноэндокринная ось у людей пожилого возраста с разным качеством жизни. Российский иммунологический журнал. 2015, 9 (18): 198-200.
- Бухарин О.В., Иванова Е.В., Перунова Н.Б. и др. Метаболический профиль бифидофлоры при различных микроэкологических состояниях биотопа толстого кишечника человека. Журн. микробиол. 2017, 1: 3-11.
- Bruunsgaard Н. Effects oftumor necrosis factor-alpha and interleukin-6 in elderly populations. Eur. Cytokine Netw. 2002, 13 (4): 389-391.
- Collins S.M., Surette M., Bercik P. The interplay between the intestinal microbiota and the brain. Nat. Rev. Microbiol. 2012, 10 (11): 735-742.
- El Aidy S., van den Bogert B., Kleerebezem M. The small intestine microbiota, nutritional modulation and relevance for health. Curr. Opin. Biotechnol. 2015, 32: 14-20.
- GuptaD., Morley J.E, Hypothalamic-pituitary-adrenal (HPA) axis and aging. Compr. Physiol. 2014.4(4): 1495-1510.
- Hollister E.B., Gao C. Versalovic J. Compositional and functional features of the gastrointestinal microbiome and their effects on human health. Gastroenterology. 2014, 146 (6): 1449-1458.
- Larsson L. Determination of microbial chemical markers by gas chromatography-mass spectrometry - potential for diagnosis and studies on metabolism in situ. APM1S. 1994, 102: 161-169.
- Leung K., Thuret S. Gut microbiota: A modulator of brain plasticity and cognitive function in aging. Healthcare. 2015, 3 (4): 898-916.
- Osipov G.A., Boiko N.B., Fedosova N.F. et al. Comparative gas chromatography-mass spectrometry study of the composition of microbial chemical markers in feces. Microbial. Ecol. Health Dis. 2009,21: 159-171.
- Rai R.V., Bai J.A. Beneficial microbes in fermented and functional foods. CRC Press. 2015, 551-571.
- Saraswati S., Sitaraman R. Aging and the human gut microbiota-from correlation to causality7. Front. Microbiol. 2014, 5: 764.
- Wagner K.H., Cameron-Smith D., Wessner B. et al. Biomarkers of aging: From function to molecular biology. Nutrients. 2016, 8 (6): 338.
Supplementary files
