PERSPECTIVES OF DEVELOPMENT OF LIVE RECOMBINANT ANTHRAX VACCINES BASED ON OPPORTUNISTIC AND APATHOGENIC MICROORGANISMS

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Abstract

Live genetic engineering anthrax vaccines on the platform of avirulent and probiotic micro-ogranisms are a safe and adequate alternative to preparations based on attenuated Bacillus anthracis strains. Mucosal application results in a direct contact of the vaccine preparations with mucous membranes in those organs and tissues of the macro-organisms, that are exposed to the pathogen in the first place, resulting in a development of local and systemic immune response. Live recombinant anthrax vaccines could be used both separately as well as in a prime-boost immunization scheme. The review focuses on immunogenic and protective properties of experimental live genetic engineering preparations, created based on members ofgeni of Salmonella, Lactobacillus and adenoviruses.

About the authors

P. Yu. Popova

Russian Research Institute for Plague Control «Microbe»

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

N. I. Mikshis

Russian Research Institute for Plague Control «Microbe»

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2016 Popova P.Y., Mikshis N.I.

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