COMPARATIVE CHARACTERISTIC'S OF IMMUNE STATUS OF PAT I ENTS WITH CHRONIC FORMS OF VIRAL HEPATITIS В, C, D AND HEALTHY INDIVIDUALS

Aim. Evaluate immune status in patients with chronic hepatitis (CH) depending on type of causative agent and severity of the infectious process. Materials and methods. 232 residents of Yakutia including 127 patients with various forms of chronic hepatitis and 105 healthy individuals were examined. Relative levels of mature T-lymphocytes (CD3⁺), T-helpers (CD4⁺), T-suppressors (CD8⁺), B-lymphocytes (CD72⁺) and natural killers (CD16⁺) were studied by flow cytometry, as well as concentration of sera immune globulins of classes A, M and G by ELISA. Results. In patients with chronic hepatitis of various forms, a decrease of expression of differentiating antigens - CD3⁺, CD4⁺, CD72⁺ on the surface of lymphocytes and concentration of sera immune globulins was established. In CHD patients in phase of monoreplication high activity of the infectious process is accompanied by a shift of immune regulatory index to the increase of activity of cytotoxic cells with simultaneous development of deficiency of mature functionally active T-lymphocytes. In the group of patients with hepatitis D virus with liver cirrhosis normal concentration of sera immune globulins is retained against the decrease of the number of T-helpers and B-lymphocytes. Conclusion. In patients with various forms of viral hepatitis acquired immune deficiency can emerge, which is often accompanied by enhancement of NK-cell activity. The noted reduction of the number of mature functionally active T-cells, as well as main classes of sera antibodies could be connected with immune system load during a chronic infectious process.

viral hepatitis, immune status, cytotoxic lymphocytes, immune deficiency state