Email this article BALANCE OF Thl/Th2/Th9/Thl7/Th22 CYTOKINES IN POST-OPERATION PERIOD IN PATIENTS WITH MALIGNANT TUMOR OF LIVER
- Authors: Aleksanyan G.B.1, Akhmatova E.A.2, Akhamtova N.K.2, Kurbatova E.A.2, Panchenkov D.N.1, Zverev V.V.2
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Affiliations:
- Evdokimov Moscow State Medical-Stomatological University
- Mechnikov Research Institute of Vaccines and Sera
- Issue: Vol 94, No 2 (2017)
- Pages: 66-74
- Section: ORIGINAL RESEARCHES
- Submitted: 10.04.2019
- Published: 28.04.2017
- URL: https://microbiol.crie.ru/jour/article/view/144
- DOI: https://doi.org/10.36233/0372-9311-2017-2-66-74
- ID: 144
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Abstract
Aim. Evaluate cytokine status in patients with malignant liver cells after surgery. Materials and methods. 33 patients aged 35 to 76 years were included into the study. Blood was obtained before the operation and in the post-operation period: after 6 and 24 hours and at day 7. Cytokine profile (IL-lb, IL-2, TNF-a, IFN-y, IL-12p70, IL-4, IL-5, IL-6, IL-10, IL-13, IL-9, II- 17a, IL-22) was evaluated using Multiplex-13 system (Bender MedSystems, Austria). Results. Inpatients levels of all the studied cytokines (Thl/Th2/Th9/Th 17/Th22) were already increased before the operations, that gives evidence of the presence of an inflammatory process connected with activation ofimmune system effectors. Conclusion. Disbalance of cytokine system helper cells resulting in functional and organic alterations through induction of the “cytokine storm” may aggravate the state of these patients. Further studies on the correction of cytokine system in these patients are thus needed.
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About the authors
G. B. Aleksanyan
Evdokimov Moscow State Medical-Stomatological University
Author for correspondence.
Email: noemail@neicon.ru
Россия
E. A. Akhmatova
Mechnikov Research Institute of Vaccines and Sera
Email: noemail@neicon.ru
Россия
N. K. Akhamtova
Mechnikov Research Institute of Vaccines and Sera
Email: noemail@neicon.ru
Россия
E. A. Kurbatova
Mechnikov Research Institute of Vaccines and Sera
Email: noemail@neicon.ru
Россия
D. N. Panchenkov
Evdokimov Moscow State Medical-Stomatological University
Email: noemail@neicon.ru
Россия
V. V. Zverev
Mechnikov Research Institute of Vaccines and Sera
Email: noemail@neicon.ru
Россия
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