BALANCE OF Thl/Th2/Th9/Thl7/Th22 CYTOKINES IN POST-OPERATION PERIOD IN PATIENTS WITH MALIGNANT TUMOR OF LIVER

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Abstract

Aim. Evaluate cytokine status in patients with malignant liver cells after surgery. Materials and methods. 33 patients aged 35 to 76 years were included into the study. Blood was obtained before the operation and in the post-operation period: after 6 and 24 hours and at day 7. Cytokine profile (IL-lb, IL-2, TNF-a, IFN-y, IL-12p70, IL-4, IL-5, IL-6, IL-10, IL-13, IL-9, II- 17a, IL-22) was evaluated using Multiplex-13 system (Bender MedSystems, Austria). Results. Inpatients levels of all the studied cytokines (Thl/Th2/Th9/Th 17/Th22) were already increased before the operations, that gives evidence of the presence of an inflammatory process connected with activation ofimmune system effectors. Conclusion. Disbalance of cytokine system helper cells resulting in functional and organic alterations through induction of the “cytokine storm” may aggravate the state of these patients. Further studies on the correction of cytokine system in these patients are thus needed.

About the authors

G. B. Aleksanyan

Evdokimov Moscow State Medical-Stomatological University

Author for correspondence.
Russian Federation

E. A. Akhmatova

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

N. K. Akhamtova

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

E. A. Kurbatova

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

D. N. Panchenkov

Evdokimov Moscow State Medical-Stomatological University

Russian Federation

V. V. Zverev

Mechnikov Research Institute of Vaccines and Sera

Russian Federation

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Copyright (c) 2017 Aleksanyan G.B., Akhmatova E.A., Akhamtova N.K., Kurbatova E.A., Panchenkov D.N., Zverev V.V.

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