ROLE OF INFECTIOUS AGENTS IN THE EMERGENCE OF MALIGNANT TUMORS


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Abstract

According to the data of the International Agency for Research on Cancer (IARC), at least 6 virus species
(HPV, EBV, HHV-8/KSHV, HTLV-1, HBV, HCV), 4 helminthes species (Schistosoma haematobium and
japonicum, Opisthorchis viverrini, Clonorchis sinensis) and 1 bacterium species (Helicobacter pylori) have been
proved to be capable of causing the development of cancer. The analysis of the data available shows that
Merkel cell polyomavirus (MCV), herpes simplex virus (HSV), John Cunningham polyomavirus (JCV),
monkey virus 40 (SV40), cytomegalovirus (CMV), xenotropic murine leukemia virus (XMRV), Helicobacter
bilis and hepaticus, Campylobacter jejuni, Fusobacterium varium, enteropathogenic Escherichia coli, enterotoxigenic
Bacteroides fragilis, Bacteroides vulgatus, Prevotella spp., Streptococcus bovis and anginosus, Treponema
denticola, Salmonella typhi, paratyphi and typhimurium, Borrelia burgdorferi, Bartonella spp., Mycobacterium
tuberculosis, Chlamydia pneumoniae, trachomatis and psittaci, Neisseria gonorrhoeae, Propionibacterium acnes,
Tropheryma whippelii, Schistosoma mansoni, Opistorchis felineus, Strongyloides stercoralis, Taenia solium,
Candida spp., Paracoccidioides brasiliensis, Histoplasma capsulatum and Trichomonas vaginalis can also be
potential etiological agents of cancer. Apparently, detection of new associations between infectious agents
and risk of the development of cancer will facilitate progress in elaboration of prophylaxis measures, early
diagnostic methods and, probably, methods of treatment of malignant tumors.

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