LOW-MANIFEST INFECTIONS IN CHILDREN AND ADOLESCENTS WITH CONSEQUENCES OF PERINATAL DAMAGE OF NERVOUS SYSTEM

Aim. Study the specter of low-manifest infections (LMI) and their role in children and adolescents with
diseases of central nervous system (CNS) against the background of consequences of perinatal damage of
nervous system (PDNS). Materials and methods. Infectologic and neurologic examinations were carried out
in 42 patients with consequences of PDNS (17 girls and 25 boys, 3 - 15 years). Detection of LMI resulted
in etiotropic therapy with evaluation of clinical and laboratory data in dynamics. Results. In 93% (39/42) of
patients causative agents of LMI were diagnosed in various combinations and in various biological materials.
Among those: Chlamydia spp. - in 71% of patients, Mycoplasma spp. - in 31%, Ureaplasma urealyticum - in
14% (in total the listed microorganisms were diagnosed in 83% of patients); Herpesviridae family viruses - in
75% (HHV-6 - in 67%, VEB - in 36%, CMV - in 11%, HSV-1,2 - in 11%). Combination of Chlamydia
spp. with HHV-6 (R tetr=+0,61) and with VEB (R tet=+0,74) (P<0,05) was detected. None of the patients
had typical signs of encephalitis clinically or based on MRT. MRT signs of gliosis-atrophic changes in the
CNS were detected in all the patients. Reduction of a number of psycho-neurologic and neurologic syndromes
was noted in all the patients during LMI therapy. Conclusion. Most of the patients with consequences of PDNS
had low-intensity inflammatory-degenerative process in the CNS determined by LMI, first of all by Chlamydia
spp. as well as Mycoplasma spp.

perinatal infections, consequences of perinatal damage of nervous system, chlamydia and mycoplasma infections of central nervous system