Email this article LOW-MANIFEST INFECTIONS IN CHILDREN AND ADOLESCENTS WITH CONSEQUENCES OF PERINATAL DAMAGE OF NERVOUS SYSTEM
- Authors: Vaynshenker Y.I1, Kalinina OV1, Nuralova IV1, Ivchenko IM1, Melyucheva LA1, Tsinzerling VA1
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Affiliations:
- Issue: Vol 89, No 5 (2012)
- Pages: 77-80
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/14216
- ID: 14216
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Abstract
diseases of central nervous system (CNS) against the background of consequences of perinatal damage of
nervous system (PDNS). Materials and methods. Infectologic and neurologic examinations were carried out
in 42 patients with consequences of PDNS (17 girls and 25 boys, 3 - 15 years). Detection of LMI resulted
in etiotropic therapy with evaluation of clinical and laboratory data in dynamics. Results. In 93% (39/42) of
patients causative agents of LMI were diagnosed in various combinations and in various biological materials.
Among those: Chlamydia spp. - in 71% of patients, Mycoplasma spp. - in 31%, Ureaplasma urealyticum - in
14% (in total the listed microorganisms were diagnosed in 83% of patients); Herpesviridae family viruses - in
75% (HHV-6 - in 67%, VEB - in 36%, CMV - in 11%, HSV-1,2 - in 11%). Combination of Chlamydia
spp. with HHV-6 (R tetr=+0,61) and with VEB (R tet=+0,74) (P<0,05) was detected. None of the patients
had typical signs of encephalitis clinically or based on MRT. MRT signs of gliosis-atrophic changes in the
CNS were detected in all the patients. Reduction of a number of psycho-neurologic and neurologic syndromes
was noted in all the patients during LMI therapy. Conclusion. Most of the patients with consequences of PDNS
had low-intensity inflammatory-degenerative process in the CNS determined by LMI, first of all by Chlamydia
spp. as well as Mycoplasma spp.
About the authors
Yu I Vaynshenker
O V Kalinina
I V Nuralova
I M Ivchenko
L A Melyucheva
V A Tsinzerling
References
- Башмакова М.А., Савичева А.М., Евсюкова И.И., Кошелев Н.Г. Генитальный хламидиоз: исходы беременности и проявление инфекции у доношенных новорожденных. В: Актуальные микробиологические и клинические проблемы хламидийных инфекций. А.Шаткин, Ж. Орфил (ред.). М., тип. Мосметростроя, 1990, с. 52-55.
- Вайншенкер Ю.И., Шатров В.А., Позняк А.Л. и др. Два случая хронического перинатального хламидийного энцефалита с первично и вторичнопрогрессирующим течением. Вестник СПбГМА им. И.И.Мечникова, 2006, 4 (7): 225-228.
- Вайншенкер Ю.И., Шатров В.А., Позняк А.Л. и др. Перинатальный хронический демиелинизирующий энцефалит, обусловленный Chlamydia trachomatis. Случай из практики. Журн. неврол. психиат. 2007, 10: 81-84.
- Цинзерлинг В.А., Мельникова В.Ф. Перинатальные инфекции (вопросы патогенеза, морфологической диагностики и клинико-морфологических сопоставлений). СПб, Элби-СПб, 2002.
- Цинзерлинг В.А., Чухловина М.Л. Инфекционные поражения нервной системы (вопросы этиологии, патогенеза и диагностики). СПб, Элби-СПб, 2011.
- Viscardi R.M. Ureaplasma species: role in diseases of prematurity. Clin. Perinatol. 2010, 37 (2): 393-409.
- Waites K.B., Katz B., Schelonka R.L. Mycoplasmas and ureaplasmas as neonatal pathogens. Clin. Microbiol. Rev. 2005, 18 (4): 757-789
- Wang I.J., Lee P.I., Huang L.M. et al. The correlation between neurological evaluations and neurological outcome in acute encephalitis: a hospitalbased study. Eur. J. Pediatr. Neurol. 2007, 11 (2): 63-69.
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