SYSTEMIC ENDOTOXINEMIA AS A PATHOGENETIC FACTOR OF PREGNANCY COMPLICATION

Aim. Evaluation of the role of hemocirculation of a bacterial endotoxin in pregnancy complicated with
gestosis. Materials and methods. A complex clinical-laboratory examination of 74 pregnant women at the
II-III trimester of gestational period including determination of serum cytokine levels (TNFƒ, IL-1ƒ, IL-2,
IL-4, IL-6, IL-8, IL-10, IFNƒ), C-reactive protein, LPS, LPS-binding protein and IgG against R-core LPS
in blood plasma was performed. Results. In pregnant women with gestosis an increase in endotoxinemia
level (p<0.0001), twofold increase in IgG titers against R-core LPS (p<0.01) and an increase in LBP concentration
by 14% (p<0.05) without an increase in concentration of C-reactive protein were shown. Cytokine
profile in gestosis was characterized by a twofold statistically significant increase of IL-1ƒ (p<0.0001), IL-8
(p<0.0001) pro-inflammatory cytokine levels, a tendency of IL-6 (p=0.063), TNFƒ (p=0.13) increase and
a decrease of Th1 cytokine concentrations: IL-2 - by 6.5 times (p<0.0001), IFNƒ - by 2 times (p<0.0001).
Conclusion. The results allow to consider gestoses as a manifestation of increased endotoxin translocation
into systemic blood flow during gestation, that determines the necessity to improve therapeutic measures in
this pathology.

IgG, gestoses, LPS, serum cytokines, IgG, LPS-binding protein