FEATURES OF DYNAMICS OF SERA CYTOKINES IN PATIENTS WITH ERYTHEMA MULTIFORME DURING IMMUNOTHERAPY


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Abstract

Aim. Study the features of cytokine profile in patients with exudative erythema multiforme (EME) and dynamics of basal level of pro-inflammatory and anti-inflammatory cytokines during immunotherapy. Materials and methods. 39 adult patients with erythema multiforme were examined. The patients were split into groups based on therapy variant. One group (14 individuals) received Immunovac-VP-4 against the background of basic therapy; the other (12 individuals) - cagocel against the background of basic therapy; comparison group (13 individuals) received only basic therapy; 15 individuals composed a group of healthy individuals. All the patients had the level of pro-, anti-inflammatory and regulatory cytokines determined in blood sera by solid-phase EIA method by using Biosource (Austria) test-systems at the beginning of the study and after the therapy. Results. In patients with exudative erythema multiforme Immunovac-VP-4 therapy facilitated a significant (p>0,05) increase of serum IFN-γ level, insignificant (p>0,05) increase of IL-1β and decrease of IL-17. Whereas cagocel lead to an increase of IL-4 (p>0,05), IL-2, IFN-γ (p>0,05) and decrease of TGF-β and IL-12 (p>0,05). At the same time basic therapy facilitated a significant increase of IL-5 and decrease of IL-6, IL-12, IFN-γ. Conclusion. Immunovac-VP-4 facilitates the increase of secretion of IFN-γ, IL-1β against the background of TGF-β that facilitates normalization of cooperation of cells in immune response including against viral infections, and thereby influencing the trigger factor in EME patients.

About the authors

E. V Sorokina

Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

N. K Akhmatova

Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

V. G Khomenkov

Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

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Copyright (c) 2014 Sorokina E.V., Akhmatova N.K., Khomenkov V.G.

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