EVALUATION OF SEROCONVERSION AFTER VACCINATION OF MEDICAL STAFF AGAINST HBV INFECTION


Cite item

Full Text

Abstract

Aim. Carry out analysis of formation of immune response in vaccinated medical staff against viral hepatitis B, detect risk factors by lack of seroconversion after vaccination. Materials and methods. In medical staff (49 individuals) retrospective analysis of dynamics of antibody titers against HBsAg (aHBs) after vaccination in 1998-2011, data on objective status and main laboratory parameters based on medical documentation was carried out. Results. Among vaccinated the lack of response (аHBs<10 mIU/ml) was observed in 20.4%, weak response (аHBs >10 mIU/ml<100 mIU/ ml) - in 34.7% and full response (аHBs>100 mIU/ml) - in 44.9% of staff. Age over 40 years, male gender, obesity and insulin-resistance were linked with ineffectiveness of vaccination. With аHBs<100 mIU/ml titers the patients became seornegative within 3 years after the immunization. With аHBs≥100 mIU/ml titers the patients remained seropositive for 10 years. Conclusion. Age over 40 years, male gender, obesity and insulin-resistance are linked with lack of formation of seroconversion after vaccination against HBV infection. When immune response is weak early monitoring of HBV titers is necessary with the aim of timely execution of revaccination. When immune response is adequate, revaccination is possible in 10 years.

About the authors

L. I Tkachenko

Stavropol State Medical Academy, Russia

V. V Maleev

Central Research Institute of Epidemiology, Moscow, Russia

L. S Putrenok

Stavropol Regional Clinical Consultation-Diagnostic Centre, Russia

References

  1. Афанасьева Г. А. Механизмы индукции и потенциирования системных цитопатогенных эффектов токсинов Yersinia pestis и принципы их медикаментозной коррекции. Автореф. дис. д-ра. мед. наук. Саратов, 2009.
  2. Демидова Г.В., Зюзина В.П., Соколова Е.П. и др. Токсичность липополисахаридов вакцинного штамма Yersinia pestis EV76 для белых мышей, сенсибилизированных D-галактозамином. Журн. микробиол. 2011, 1: 74-76.
  3. Соколова Е. П. Механизмы активации токсических субстанций чумного микроба. Автореф. дис. канд. биол. наук. Ростов-на-Дону, 2002.
  4. Соколова Е.П., Демидова Г.В., Зюзина В.П. и др. Динамика синтеза TNF-α и INF-γ моноцитами человека под действием липополисахаридов Yersinia pestis EV 76 с различной степенью токсичности. Журн. микробиол. 2010, 4: 59-64.
  5. Соколова Е.П., Демидова Г.В., Зюзина В.П. и др. Токсичность и цитокининдуцирующая активность ЛПС вирулентного штамма Yersinia pestis 231. Журн. микробиол. 2011, 6: 20-26.
  6. Соколова Е.П., Зюзина В.П., Демидова Г.В. и др. Исследование цитокининдуцирующей активности различных форм липополисахаридов Y. pestis EV 76 моноцитами человека. Известия высших учебных заведений. Северо-Кавказский регион. Естеств. науки. 2012, 2: 75-78.
  7. Biswar S. K., Brist P., Dhillon M. K. Role for MyD-88independent, TRIF pathway in lipid A/ TLR4-induced endotoxin tolerance. J. Immunol. 2007, 179: 4083-4092.
  8. Carpenter S., O'Neill L. Recent insights into structure of Toll-like receptors and post-translation modification of their associated signaling proteins. Biochem. J. 2009, 422: 1-10.
  9. Dalpke A., Lehner M. D., Hartung T. et al. Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology. 2005, 116: 203-212.
  10. Matsuura M., Takahashi H., Watanabe H. et al. Immunomodulatory properties of Yersinia pestis lipopolysaccharides on human macrophages. Clin. Vaccine Immunol. 2010, 17 (1): 49-55.
  11. Montminy S., Khan N., McGrath S. et al. Virulent factors ofYersinia pestis are overcome by a strong lipopolysaccharide response. Nature Immun. 2006, 7 (10): 1066-1073.
  12. Nahid Md A., Satoh M., Chan E. MicroRNA in TLR signaling and endotoxin tolerance. Cell. Mol. Immunol. 2011, 8: 383-403.
  13. Sato S., Nomura F., Kawai T. et al. Synergy and cross-tolerance between toll-like receptor (TLR)2-and TLR4-mediated signaling pathways. 2000, 165: 7096-7101.
  14. Uematsu S., Akira S. Toll-like receptors and type I interferons. J. Biol. Chem. 2007, 282 (21): 15191532.
  15. Westphal O., Jann K. Bacterial lipopolysaccharides extraction with phenol-water and further applications of the procedure. Methods carbohydr. Chem. 1965, 5: 83-91.
  16. Zughaier S. M., Zimmer S. M., Datta A. et al. Differential induction of the Toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endonoxins. Infect. Immun. 2005, 73 (5): 2940-2950.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Tkachenko L.I., Maleev V.V., Putrenok L.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС77-75442 от 01.04.2019 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies