SPREAD OF HERPESVIRUS INFECTIONS IN CHILDREN AND ADULTS IN ST. PETERSBURG ACCORDING TO SEROEPIDEMIOLOGIC STUDY DATA


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Abstract

Aim. Complex study of seropositivity of adult individuals and children to human herpes viruses of 6 types. Materials and methods. 2322 individuals (1000 adults donors and 1322 children aged 1 - 17 years) residing in St. Petersburg were examined. Seropositivity to human herpes viruses types 1, 2, 4, 5, 6 and 8 was studied by enzyme immunoassay methods. Results. A high proportion of individuals seropositive to cytomegalovirus (CMV) and herpes simplex virus (HSV) as well as high frequency of simultaneous presence of antibodies against various types of human herpes virus (HHV) was detected. A clear tendency of increase with age of frequency of detection of antibodies against most HHV was detected. The sharpest increase of seropositivity to HSV, HHV-8, CMV, Epsetin-Barr virus (EBV) is noted in a group of 12 - 17 year old children, that is probably connected with activation of sexual transmission. The proportion of seropositivity in this age group was: to HSV - 65%, HHV-6 - 13%, HHV-8 - 3.3%, CMV - 80%, EBV - 61.7% against 74.8%, 68.4%, 2.7%, 80.9%, 41.8% in donors, respectively. Conclusion. Further studies determining temporal trends of population infection, connection of seropositivity with frequency of manifest forms of infections, seropositivity of risk groups are needed.

About the authors

A. B Zhebrun

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

L. B Kulyashova

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

K. D Ermolenko

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

A. V Zakrevskaya

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

References

  1. Асранкулова Д.Б. Эпидемиологические особенности цитомегаловирусной инфекции среди различных контингентов населения. Эпидемиол. инфекц. бол. 2003, 3: 19-21.
  2. Львов Д.К. (ред). Организация эколого-эпидемиологического мониторинга территории Российской Федерации. Методические рекомендации. М., 1995.
  3. Львов Д.К., Баринский И.Ф. Лазаренко А.А.и др. Иммунизация вакциной «Витагерпавак» (герпетическая культуральная инактивированная сухая) для профилактики рецидивов инфекции, обусловленной вирусами простого герпеса 1 и 2 типов. Методические рекомендации. Федеральный центр гигиены и эпидемиологии Роспотребнадзора, 2010.
  4. Молочков А.В., Казанцева И.А., Гурцевич В.Э. Саркома Капоши. М., Бином, 2002.
  5. Юнкеров В.И., Григорьев С.Г. Математико-статистическая обработка данных медицинский исследований. Спб, 2002.
  6. Ющук Н.Д., Кускова Т.Г., Венгеров Ю.Я.и др. Герпесвирусные инфекции. М., ГЭОТАР-Медиа, 2011.
  7. Alfieri C., Tanner J., Carpentier L. et al. Epstein-Barr virus transmission from a blood donor to an organ transplant recipient with recovery of the same virus strain from the recipient's blood and oropharynx. Blood. 1996, 87 (2): 812-817.
  8. Belshe R. B., Leone P. A., Bernstein D. I. et al. Efficacy results of a trial of a herpes simplex vaccine. N. Engl. J. Med. 2012, 366: 34-43.
  9. Brown Z. A., Wald A., Morrow R. A. et al. Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA. 2003, 289 (2): 203-209.
  10. CDC. Division of STD Prevention. Sexually Transmitted Disease Surveillance 2011. December 2012.
  11. Johnson J., Anderson B., Pass R.F Prevention of maternal and congenital cytomegalovirus infection. Clin. Obstet. Gynecol. 2012, 55 (2): 521-530.
  12. Hall C.B. Epidemiology of HHV6 perspectives in medical virology. Elsevier, 2006.
  13. Higgins C. D., Swerdlow A. J., Macsween K. F. N. et al. A study of risk factors for acquisition of epstein-barr virus and its subtypes. J. Infect. Dis. 2007, 195: 474-482.
  14. Hladik W, Dollard S.C., Mermin J. et al. Transmission ofhuman herpesvirus 8 by blood transfusion. N. Engl. J. Med. 2006, 355: 1331-1338.
  15. Looker K.J., Garnett G.P., Schmid G.P. An estimate of the global prevalence and incidence ofher-pes simplex virus type 2 infection. Bull. World Health Organ. 2008, 86 (10): 805-812
  16. Lopo S., Vinagre E., Palminha P. et al. Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003. Euro. Surveilancel. 2011, 23: 16-25.
  17. Malkin J.E. Epidemiology of genital herpes simplex virus infection in developed countries. Herpes. 2004, 11 (1): 2A-23A.
  18. Pebody R. G., Andrews N., Brown D. et al. The seroepidemiology of herpes simplex virus type 1 and 2 in Europe. Sex. Transm. Infect. 2004, 80: 185-191.
  19. Rezza G., Tchangmena O.B., Andreoni M. et al. Prevalence and risk factors for human herpesvirus 8 infection in northern Cameroon. Sex. Transm. Dis. 2000, 27: 159-164.
  20. Roberts C.M., Pfister J.R., Spear S.J.Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex. Transm. Dis. 2003, 30 (10): 797-800.
  21. Staras S.A., Dollard S.C., Radford K.W. et al. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin. Infect. Dis. 2006, 43 (9): 1143-1151.
  22. Whitby D., Luppi M., Sabin C. et al. Detection of antibodies to human herpesvirus 8 in italian children: evidence for horizontal transmission. Br. J. Cancer. 2000, 82 (3): 702-704.

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Copyright (c) 2013 Zhebrun A.B., Kulyashova L.B., Ermolenko K.D., Zakrevskaya A.V.

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