FORMATION OF FOCUS OF WEST NILE FEVER ON THE TERRITORY OF SARATOV REGION


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Abstract

Aim. Detection of circulation ofWest Nile virus (WNV) on the territory of Saratov Region and prerequisites for formation of natural focus of West Nile fever (WNF), determination of the role ofWNV in infectious pathology on the territory of the region. Materials and methods. Suspensions of organs of small mammals, birds, blood-sucking arthropods for the presence of WNV markers (antigens and/or RNA) were studied. Clinical material from patients with symptoms not excluding WNF was studied. Donor blood sera samples were analyzed with the aim of detection of immune layer against WNV in population of Saratov Region. Results. In 2010 WNV antigens were detected by EIA in 12 samples (7.1%) of mammal organ suspensions. In 2012 by using RT-PCR and EIA, markers of WNV were detected in 6 samples of bird brain suspensions (6.3%) and 1 sample of mammal organ suspension. Immune layer of population against WNV was 4% in 2011, 2.8% in 2012. In 2012 in 11 of 27 examined patients IgM against WNV in diagnostic titers and/or serconversion of IgG in paired sera were detected. In addition in 5 individuals virus RNA was detected in blood. Based on clinical, laboratory data and epidemiologic anamnesis 11 patients were diagnosed with WNF. Conclusion. The results obtained give evidence on the circulation of WNV on the territory of Saratov Region in 2010 - 2012. With the development of complications ofWNF epidemiologic situation in 2012 an expansion ofWNV areal onto the territory of the region took place and the process of formation of WNF natural foci is ongoing.

About the authors

T. Yu Krasovskaya

Russian Research Institute of Plague Control «Microbe», Russia

I. N Sharova

Russian Research Institute of Plague Control «Microbe», Russia

E. V Naidenova

Russian Research Institute of Plague Control «Microbe», Russia

V. N Chekashov

Russian Research Institute of Plague Control «Microbe», Russia

S. A Scherbakova

Russian Research Institute of Plague Control «Microbe», Russia

E. A Bilko

Russian Research Institute of Plague Control «Microbe», Russia

V. E Kuklev

Russian Research Institute of Plague Control «Microbe», Russia

A. N Matrosov

Russian Research Institute of Plague Control «Microbe», Russia

S. A Yakovlev

Russian Research Institute of Plague Control «Microbe», Russia

A. M Porshakov

Russian Research Institute of Plague Control «Microbe», Russia

M. M Shilov

Russian Research Institute of Plague Control «Microbe», Russia

A. A Kuznetsov

Russian Research Institute of Plague Control «Microbe», Russia

T. V Knyazeva

Russian Research Institute of Plague Control «Microbe», Russia

A. M Senichkina

Russian Research Institute of Plague Control «Microbe», Russia

E. V Kazorina

Russian Research Institute of Plague Control «Microbe», Russia

N. V Popov

Russian Research Institute of Plague Control «Microbe», Russia

Z. P Fedorova

Administration of Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Saratov Region, Russia

U. A Kresova

Centre of Hygiene and Epidemiology in Saratov Region, Saratov, Russia

E. A Talaeva

City Hospital No. 2, Engels, Saratov Region, Russia

N. I Mironova

City Clinical Hospital No. 2, Saratov, Russia

O. I Kozhanova

Administration of Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Saratov Region, Russia

V. V Kutyrev

Russian Research Institute of Plague Control «Microbe», Russia

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Copyright (c) 2013 Krasovskaya T.Y., Sharova I.N., Naidenova E.V., Chekashov V.N., Scherbakova S.A., Bilko E.A., Kuklev V.E., Matrosov A.N., Yakovlev S.A., Porshakov A.M., Shilov M.M., Kuznetsov A.A., Knyazeva T.V., Senichkina A.M., Kazorina E.V., Popov N.V., Fedorova Z.P., Kresova U.A., Talaeva E.A., Mironova N.I., Kozhanova O.I., Kutyrev V.V.

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