Email this article INFLUENCE OF PLANT EXTRACTS ON THE ACTIVITY OF CHOLERA TOXIN OF VIBRIO CHOLERAE
- Authors: Markina O.V1, Alekseeva L.P1, Markin N.V2, Telesmanich N.R1
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Affiliations:
- Rostov-on-Don Research Institute of Plague Control
- Research Institute of Biology of Southern Federal University, Rostov-on-Don, Russia
- Issue: Vol 90, No 1 (2013)
- Pages: 9-13
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13790
- ID: 13790
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Abstract
Aim . Study the activity of plant extracts against cholera toxin (CT) of Vibrio cholerae O1. Materials and methods. Antitoxic activity of plant extracts was determined by using enzyme immunoassay and CHO-K1 cell culture. Results. 8 water extracts of plants were studied. Extracts of nut, tutsan, milfoil, basil do not have effect on CT activity in EIA or CHO-K1 cell culture. Celandine and rhubarb extracts do not reduce CT immunochemical activity but prevent elongation of CHO-K1 cells. Oak and hop extracts suppress binding in EIA of cholera toxin and GM1 receptors and in- significantly reduce its activity in cell culture. Conclusion. Antitoxic activity of plant extracts against CT is perspective for the development of preparations possessing inhibition effect.
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Full Text
ВЛИЯНИЕ ЭКСТРАКТОВ РАСТЕНИЙ НА АКТИВНОСТЬ ХОЛЕРНОГО ТОКСИНА VIBRIO CHOLERAE×
About the authors
O. V Markina
Rostov-on-Don Research Institute of Plague Control
L. P Alekseeva
Rostov-on-Don Research Institute of Plague Control
N. V Markin
Research Institute of Biology of Southern Federal University, Rostov-on-Don, Russia
N. R Telesmanich
Rostov-on-Don Research Institute of Plague Control
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