Email this article EPITHELIAL-BACTERIAL INTERACTIONS AS A BASIS OF MICROBIOCENOSIS FORMATION
- Authors: Kremleva EA1, Cherkasov SV1, Bukharin OV1, Kremleva EA2, Cherkasov SV3, Bukharin OV3
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Affiliations:
- Research Institute of Cellular and Intracellular Symbiosis, OrenburgOrenburg State Medical Academy, Russia
- Research Institute of Cellular and Intracellular Symbiosis, Orenburg
- Issue: Vol 89, No 6 (2012)
- Pages: 95-99
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13761
- ID: 13761
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Abstract
Materials and methods. Effect of vaginal epitheliocytes on growth properties of lactobacilli strains
obtained from the same biotope from 16 women with vaginal normocenosis was studied. During intravaginal
probiotic therapy in 24 women with vaginal dysbiosis probability of colonization of vagina by probiotic strain
was evaluated depending on the result of effect of vaginal epitheliocytes on its growth properties. Results.
Exometabolites of epitheliocytes in normocenosis were shown to render stimulating effect on the growth of
autostrain of dominant microflora, that probably is the basis of formation and/or support of microbiocenosis.
Stimulating effect of exometabolites of vaginal epitheliocytes of patients on growth properties of probiotic
strain was revealed to be the prerequisite for successful probiotic therapy. Conclusion. The data obtained
allow to examine epithelial-bacterial interactions as a basis of formation of microbiocenoses. Evaluation of
these interactions may be used for individual selection of probiotic strains.
About the authors
E A Kremleva
S V Cherkasov
O V Bukharin
E A Kremleva
Research Institute of Cellular and Intracellular Symbiosis, OrenburgOrenburg State Medical Academy, RussiaResearch Institute of Cellular and Intracellular Symbiosis, OrenburgOrenburg State Medical Academy, Russia
S V Cherkasov
Research Institute of Cellular and Intracellular Symbiosis, OrenburgResearch Institute of Cellular and Intracellular Symbiosis, Orenburg
O V Bukharin
Research Institute of Cellular and Intracellular Symbiosis, OrenburgResearch Institute of Cellular and Intracellular Symbiosis, Orenburg
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