Email this article HUMORAL IMMUNE RESPONSE IN PATIENTS WITH ANGINA AND SOFT TISSUE INFEC -TIONS OF GROUP A STREPTOCOCCI ETIOLOGY
- Authors: Kleymenov DA1, Glushkova EV1, Dmitrieva NF1, Eshchina AS1, Timofeev Y.M1, Malyshev NA1, Briko NI1, Kleymenov DA2, Glushkova EV2, Dmitrieva NF2, Eschina AS2, Timofeev Y.M2, Malyshev NA2, Briko NI2
-
Affiliations:
- Sechenov First Moscow State Medical University, Russia
- Issue: Vol 89, No 6 (2012)
- Pages: 76-80
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13740
- ID: 13740
Cite item
Full Text
Abstract
against streptolysin-O - ASL-O) and cellular (IgM against A-polysaccharide - A-PSC) antigens in patients
with angina and soft tissue infections caused by serogroup A streptococci (SGA) and identify features of
humoral immune response to SGA infection according to infectious process localization. Materials and
methods. 2 groups of patients with bacteriologically confirmed SGA infection (50 cases of angina - group 1
and 51 case of soft tissue infection - group 2) were examined for the presence of ASL-O by using Architect
ci8200 analyzer (Abbott, USA) and IgM against SGA A-PSC by EIA. Results. In group 1, 23 (46%) individuals
were recognized as positive by ASL-O level, and in group 2 - 20 (39%; p>0.05); conditionally significant
exceeding of normal values (more than 1.5 times) was detected in 25% of patients of each group.
Increased level of antibodies against SGA A-PSC was detected in 43 (86%) patients of group 1, and in 30
(59%) of patients of group 2 (p<0.05). In group 1 exceeding of normal values of anti-A-PSC IgM was noted
mostly by 1.50.5 times (74%). In group 2 in 43% of patients the level of anti-A-PSC IgM was above normal
more than 2 times and in most cases in uncomplicated variants of disease course. In 45% of patients with
severe form of soft tissue infection this parameter did not exceed normal values (p<0.05). Conclusion. In acute
period of disease with simultaneous determination of ASL-O and IgM against A-PSC sensitivity of serologic
diagnostics of SGA etiology angina and SGA infection of soft tissues was established to reach 92% and
72%, respectively, and humoral immune response to cellular AG in each form of SGA has its features.
Keywords
About the authors
D A Kleymenov
E V Glushkova
N F Dmitrieva
A S Eshchina
Yu M Timofeev
N A Malyshev
N I Briko
D A Kleymenov
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
E V Glushkova
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
N F Dmitrieva
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
A S Eschina
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
Yu M Timofeev
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
N A Malyshev
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
N I Briko
Sechenov First Moscow State Medical University, RussiaSechenov First Moscow State Medical University, Russia
References
- Клейменов Д.А. Эпидемиологическая характеристика стрептококковой (группы А) инфекции и предложения по улучшению ее иммунологической диагностики. Автореф. дисс. канд. мед. наук. М., 2009.
- Мясоедова С.Е., Андреева Д.В., Бобков В.А. и др. Оценка секреторного и гуморального иммунного ответа на групповой полисахарид А при ревматизме. Клиническая лабораторная диагностика. 1996, 4: 43-45
- Покровский В.И., Брико Н.И., Ряпис Л.А. Стрептококки и стрептококкозы. М., ГЭОТАР- Медиа, 2006.
- Ряпис Л.А., Брико Н.И., Ещина А.С. и др. Стрептококки: общая характеристика и методы лабораторной диагностики. М., 2009.
- Шихман А.Р., Анохина А.Р., Николаева Л.В. и др. Определение антител к рибосомам и другим компонентам клеточной стенки и выявление циркулирующих антигенов стрептококка группы А у пациентов, больных рожей. Журн. микробиол. 1986, 12: 91-95.
- Akesson P., Rasmussen M., Mascini E. et al. Low antibody levels against cell wall-attached proteins of streptococcus pyogenes predispose for severe invasive disease. J. Infect. Dis. 2004, 189 (5): 797-804.
- Ayoub E.M., Nelson B., Shulman S.T. et al. Group A streptococcal antibodies in subjects with or without rheumatic fever in areas with high or low incidences of rheumatic fever. Clin. Diagn. Lab. Immunol. 2003, 10, (5): 886-890.
- Ben-Cherit E., Moses A.E., Agmon-Levin N. et al. Serum levels of anti-streptolysin O antibodies: their role in evaluating rheumatic diseases. Int. J. Rheum. Dis. 2012 15(1): 78-85.
- Bessen D.E., Kumar N., Hall G.S. et al. Whole genome association study on tissue tropism phenotypes in group A Streptococcus. J. Bacteriol. 2011, 193 (23): 6651-6663.
- Brandt E.R., Yarwood P.J., McMillan D.J. et al. Antibody levels to the class I and II epitopes of the M protein and myosin are related to group A streptococcal exposure in endemic populations. Int. Immunol. 2001, 13 (10): 1335-1343.
- Carapetis J.R., Steer A.C., Mulholland E.K. et al. The current evidence for the burden of group A streptococcal diseases. WHO, 2005.
- Johnson D.R., Kurlan R., Leckman J. et al. The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications. CID. 2010, 50: 481-490.
- Sabharwal H., Michon F., Nelson D. et al. Group A streptococcus (GAS) carbohydrate as an immunogen for protection against GAS infection. JID. 2006, 193: 129-135.
- Shet A., Kaplan E.L. Clinical use and interpretation of group A streptococcal antibody tests: a practical approach for the pediatrician or primary care physician. Pediatr. Infect. Dis. J. 2002, 21: 420-430.
- Swedo S.E., Leonard H.L., Garvey M. et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am. J. Psychiatry. 1998, 155: 264-271.
- Tweten R.K. Cholesterol-dependent cytolysins, a family of versatile poreforming toxins. Infect. Immun. 2005, 73: 6199-6209.
- Vincent A. Encephalitis lethargica: part of a spectrum of post-streptococcal autoimmune diseases? Brain. 2004, 127: 2-3.
- Yaddanapudi K., Hornig M., Serge R. et al. Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Mol. Psychiatry. 2010, 15: 712-726.
Supplementary files
