HUMORAL IMMUNE RESPONSE IN PATIENTS WITH ANGINA AND SOFT TISSUE INFEC -TIONS OF GROUP A STREPTOCOCCI ETIOLOGY


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Abstract

Aim. Evaluate informativity of simultaneous determination of antibodies (AB) against extracellular (AB
against streptolysin-O - ASL-O) and cellular (IgM against A-polysaccharide - A-PSC) antigens in patients
with angina and soft tissue infections caused by serogroup A streptococci (SGA) and identify features of
humoral immune response to SGA infection according to infectious process localization. Materials and
methods. 2 groups of patients with bacteriologically confirmed SGA infection (50 cases of angina - group 1
and 51 case of soft tissue infection - group 2) were examined for the presence of ASL-O by using Architect
ci8200 analyzer (Abbott, USA) and IgM against SGA A-PSC by EIA. Results. In group 1, 23 (46%) individuals
were recognized as positive by ASL-O level, and in group 2 - 20 (39%; p>0.05); conditionally significant
exceeding of normal values (more than 1.5 times) was detected in 25% of patients of each group.
Increased level of antibodies against SGA A-PSC was detected in 43 (86%) patients of group 1, and in 30
(59%) of patients of group 2 (p<0.05). In group 1 exceeding of normal values of anti-A-PSC IgM was noted
mostly by 1.50.5 times (74%). In group 2 in 43% of patients the level of anti-A-PSC IgM was above normal
more than 2 times and in most cases in uncomplicated variants of disease course. In 45% of patients with
severe form of soft tissue infection this parameter did not exceed normal values (p<0.05). Conclusion. In acute
period of disease with simultaneous determination of ASL-O and IgM against A-PSC sensitivity of serologic
diagnostics of SGA etiology angina and SGA infection of soft tissues was established to reach 92% and
72%, respectively, and humoral immune response to cellular AG in each form of SGA has its features.

About the authors

D A Kleymenov

E V Glushkova

N F Dmitrieva

A S Eshchina

Yu M Timofeev

N A Malyshev

N I Briko

D A Kleymenov

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

E V Glushkova

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

N F Dmitrieva

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

A S Eschina

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

Yu M Timofeev

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

N A Malyshev

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

N I Briko

Sechenov First Moscow State Medical University, Russia

Sechenov First Moscow State Medical University, Russia

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Copyright (c) 2012 Kleymenov D.A., Glushkova E.V., Dmitrieva N.F., Eshchina A.S., Timofeev Y.M., Malyshev N.A., Briko N.I., Kleymenov D.A., Glushkova E.V., Dmitrieva N.F., Eschina A.S., Timofeev Y.M., Malyshev N.A., Briko N.I.

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