ROL' CHLAMYDIA TRACHOMATIS I CHLAMYDOPHILA PNEUMONIAE V PORAZhENII STRUKTUR ZADNEGO SEGMENTA GLAZA

Aim. Study the ability of Chlamydia trachomatis and Chlamydophila pneumoniae to damage
structures of eye posterior segment, features of development of such infectious process, its morphological
and clinical characteristics. Materials and methods. 6 rabbits with confirmed absence
of C. trachomatis, C. pneumoniae were used in the study. 3 animals were infected with C. trachomatis
culture and 3 animals - with C. pneumoniae culture. Subconjunctival and intravitreal mode
of infectious agent introduction were used, as well as instillation of its culture into conjunctival
sac. Microbiological diagnostics included microscopy with direct immunofluorescence, culture
method and determination of antibody titers. Infectious process was studied by using ophthalmologic
methods and histological examination. Observation period was 4 months. Results. In all the
animals a development of infectious process at early stages after the infection was confirmed.
Conjunctivitis symptoms, inflammatory exudation into vitreous humor, chorioretinal inflammation
loci, disorders in transparency of optical media and detachment of retina were clinical
manifestations. In 2 animals infected with C. trachomatis severe panuveitis was noted. In 4 animals
infectious process assumed subclinical characteristics (infection with both C. trachomatis or C.
pneumoniae). In pathomorphologic studies data on the ability of C. trachomatis and C. pneumoniae
to cause damage to cells of retina, pigment epithelium and choroid were obtained. Conclusion.
C. trachomatis and C. pneumoniae may play a significant role in pathology of vitreous humor,
retina, pigment epithelium and choroid.

Chlamydia trachomatis, Chlamydophila pneumoniae, Chlamydia trachomatis, Chlamydophila pneumoniae, retina, chronic inflammation