GENETICAL FEATURES OF INFLUENZA VIRUS A (H1N1) STRAIN THAT CAUSED THE 2009 PANDEMIC


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Abstract

Genetical features of the А (H1N1) influenza virus strain that caused the 2009 pandemic are analyzed in the review. Mutations typical for this strain, unique and similar to influenza viruses of swine, avian and seasonal types, and phenotypic (pathologic) features associated with them, that are experimentally confirmed, are described. A possibility of reassortation of avian and swine influenza viruses and possible epidemiologic consequences are discussed.

About the authors

I. M Susloparov

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

K. A Sharshov

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. A Romanovskaya

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. G Durymanov

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. Yu Alekseev

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

E. A Stavsky

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

E. M Malkova

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. M Shestopalov

State Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

References

  1. Chen H., Bright R.A., Subbarao K. et al. Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice. Virus Res. 2007, 128 (1-2): 159-163.
  2. Dawood, F. S., Jain S., Finelli L. et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med. 2009, 360: 26052615.
  3. Gabriel G., Dauber B., Wolff T et al. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc. Natl. Acad. Sci. USA. 2005, 102: 18590-18595.
  4. Gamblin S.J., Haire L.F., Russell R.J. et al. The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science. 2004, 303: 1838-1842.
  5. Garten R. J., Davis C. T., Russell C. A. et al. Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Ibid. 2009, 325: 197-201.
  6. Guan Y., Poon L.L., Cheung C.Y. et al. H5N1 influenza: a protean pandemic threat. Proc. Natl. Acad. Sci. USA. 2004, 101: 8156-8161.
  7. Hatta M., Gao P., Halfmann P. et al. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science. 2001, 293: 1840-1842.
  8. Hulse-Post D.J., Franks J., Boyd K. et al. Molecular changes in the polymerase genes (pa and pb1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J. Virol. 2007, 81 (16): 8515-8524.
  9. Jing X., Ma Ch., Ohigashi Y et al. Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc. Natl. Acad. Sci. USA. 2008, 105 (31): 10967-10972.
  10. Leneva I.A., Russell R.J., Boriskin YS. et al. Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol. Antiviral Res. 2009, 81 (2): 132-140.
  11. Newman A.P., Reisdorf E., Beinemann J. et al. Human case of swine influenza A (H1N1) triple reassortant virus infection, Wisconsin. Emerg. Infect. Dis. 2008, 14 (9): 1470-1472.
  12. Obenauer J.C., Denson J., Mehta P.K. et al. Large-scale sequence analysis of avian influenza isolates. Science. 2006, 311: 1576-1580.
  13. Riquelme A., Alvarez-Lobos M., Pavez C. et al. Gastrointestinal manifestations among Chilean patients infected with novel influenza A (H1N1) 2009 virus. Gut. 2009, 58: 1567-1568.
  14. Rolling T, Koerner I., Zimmermann P. et al. Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice. J. Virol. 2009, 83 (13): 6673-6680.
  15. Shinde V., Bridges C.B., Uyeki T.M. et al. Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009. N. Engl. J. Med. 2009, 361: 1-10.
  16. Subbarao K., Shaw M.W Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Rev. Med. Virol. 2000, 10 (5): 337-348.
  17. Taubenberger J.K., Reid A.H., Lourens R.M. et al. Characterization of the 1918 influenza virus polymerase genes. Nature. 2005, 437: 889893.
  18. Tumpey TM., Maines T.R., Hoeven N. et al. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science. 2007, 315: 655-659.
  19. Webster R.G. Influenza: an emerging disease. Emerg. Infect. Dis. 1998, 4 (3): 436-441.

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Copyright (c) 2011 Susloparov I.M., Sharshov K.A., Romanovskaya A.A., Durymanov A.G., Alekseev A.Y., Stavsky E.A., Malkova E.M., Shestopalov A.M.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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