Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13613ArticlesСтатьиReview ArticleGENETICAL FEATURES OF INFLUENZA VIRUS A (H1N1) STRAIN THAT CAUSED THE 2009 PANDEMICГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ ШТАММА ВИРУСА ГРИППА A (H1N1), ВЫЗВАВШЕГО ПАНДЕМИЮ 2009 ГSusloparovI. MСуслопаровИ. МSharshovK. AШаршовК. АRomanovskayaA. AРомановскаяА. АDurymanovA. GДурымановА. ГAlekseevA. YuAлekceeвA. ЮStavskyE. AСтавскийЕ. АMalkovaE. MМалковаЕ. МShestopalovA. MШестопаловА. МState Scientific Center ofVirology and Biotechnology Vector, Koltsovo, Novosibirsk Region, RussiaГНЦ вирусологии и биотехнологии «Вектор», пос. Кольцово, Новосибирская область15102011885NO5 (2011)№5 (2011)10711009062023Copyright ©; 2011, Susloparov I.M., Sharshov K.A., Romanovskaya A.A., Durymanov A.G., Alekseev A.Y., Stavsky E.A., Malkova E.M., Shestopalov A.M.Copyright ©; 2011, Суслопаров И.М., Шаршов К.А., Романовская А.А., Дурыманов А.Г., Aлekceeв A.Ю., Ставский Е.А., Малкова Е.М., Шестопалов А.М.2011Susloparov I.M., Sharshov K.A., Romanovskaya A.A., Durymanov A.G., Alekseev A.Y., Stavsky E.A., Malkova E.M., Shestopalov A.M.Суслопаров И.М., Шаршов К.А., Романовская А.А., Дурыманов А.Г., Aлekceeв A.Ю., Ставский Е.А., Малкова Е.М., Шестопалов А.М.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13613

Genetical features of the А (H1N1) influenza virus strain that caused the 2009 pandemic are analyzed in the review. Mutations typical for this strain, unique and similar to influenza viruses of swine, avian and seasonal types, and phenotypic (pathologic) features associated with them, that are experimentally confirmed, are described. A possibility of reassortation of avian and swine influenza viruses and possible epidemiologic consequences are discussed.

В обзоре проанализированы генетические особенности вируса гриппа А (H1N1), вызвавшего пандемию 2009 г. Описаны характерные для него мутации, уникальные и схожие с вирусами гриппа свиного, птичьего и сезонного типов и связанные с ними фенотипические (патологические) особенности, которые были экспериментально подтверждены. Рассматривается возможность реассортации вирусов гриппа птиц и свиней и ее вероятные эпидемиологические последствия.

strainsgenetical featurespandemicвирус гриппа А (H1N1)штаммыгенетические особенностипандемияinfluenza virus А (H1N1)Chen H., Bright R.A., Subbarao K. et al. Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice. Virus Res. 2007, 128 (1-2): 159-163.Dawood, F. S., Jain S., Finelli L. et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med. 2009, 360: 26052615.Gabriel G., Dauber B., Wolff T et al. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc. Natl. Acad. Sci. USA. 2005, 102: 18590-18595.Gamblin S.J., Haire L.F., Russell R.J. et al. The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science. 2004, 303: 1838-1842.Garten R. J., Davis C. T., Russell C. A. et al. Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Ibid. 2009, 325: 197-201.Guan Y., Poon L.L., Cheung C.Y. et al. H5N1 influenza: a protean pandemic threat. Proc. Natl. Acad. Sci. USA. 2004, 101: 8156-8161.Hatta M., Gao P., Halfmann P. et al. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science. 2001, 293: 1840-1842.Hulse-Post D.J., Franks J., Boyd K. et al. Molecular changes in the polymerase genes (pa and pb1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J. Virol. 2007, 81 (16): 8515-8524.Jing X., Ma Ch., Ohigashi Y et al. Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc. Natl. Acad. Sci. USA. 2008, 105 (31): 10967-10972.Leneva I.A., Russell R.J., Boriskin YS. et al. Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol. Antiviral Res. 2009, 81 (2): 132-140.Newman A.P., Reisdorf E., Beinemann J. et al. Human case of swine influenza A (H1N1) triple reassortant virus infection, Wisconsin. Emerg. Infect. Dis. 2008, 14 (9): 1470-1472.Obenauer J.C., Denson J., Mehta P.K. et al. Large-scale sequence analysis of avian influenza isolates. Science. 2006, 311: 1576-1580.Riquelme A., Alvarez-Lobos M., Pavez C. et al. Gastrointestinal manifestations among Chilean patients infected with novel influenza A (H1N1) 2009 virus. Gut. 2009, 58: 1567-1568.Rolling T, Koerner I., Zimmermann P. et al. Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice. J. Virol. 2009, 83 (13): 6673-6680.Shinde V., Bridges C.B., Uyeki T.M. et al. Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009. N. Engl. J. Med. 2009, 361: 1-10.Subbarao K., Shaw M.W Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Rev. Med. Virol. 2000, 10 (5): 337-348.Taubenberger J.K., Reid A.H., Lourens R.M. et al. Characterization of the 1918 influenza virus polymerase genes. Nature. 2005, 437: 889893.Tumpey TM., Maines T.R., Hoeven N. et al. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science. 2007, 315: 655-659.Webster R.G. Influenza: an emerging disease. Emerg. Infect. Dis. 1998, 4 (3): 436-441.