EFFECT OF COMPLEX VACCINATION AGAINST PNEUMOCOCCAL, HAEMOPHILUS TYPE b INFECTIONS AND INFLUENZA IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Aim. Determination of the effect of complex vaccination with Pneumo-23, Hiberix, Grippol plus on sputum bacterial content 6 months after the vaccination of patients with chronic obstructive pulmonary disease (COPD) compared with unvaccinated patients. Materials and methods. Bacteriological analysis of sputum obtained for 6 months from 80 patients with COPD was carried out. The first group of 31 patients with COPD was immunized simultaneously with Pneumo-23, Hiberix, Grippol plus (mean age - 59.25±1.12). The second group consisted of 49 unvaccinated patients with COPD (mean age - 57.16±0.98). Classical microbiological method was used in the study. Results. 6 months after the complex vaccination a significant decrease to 35.48±8.59% of vaccinated patients, that expectorate sputum with Streptococcus pneumoniaе , compared with 80.65±7.1% in unvaccinated patients with COPD was observed. Conclusion. A combined vaccination against pneumococcal, haemophilus type b infection and influenza carried out with a prophylactic and therapeutic goal is recommended for patients with COPD as a part of the treatment and prophylaxis complex measures.

vaccination of patients with chronic obstructive pulmonary disease, vaccination against pneumococcal haemophilus type b infection and influensa