IMMUNOLOGICAL AND BACTERIOLOGICAL MONITORING OF PATIENTS WITH PNEUMONIA AND INFLUENZA A/H1N1 INFECTION

Aim. To study features of immune status and causative agents of severe pneumonia in patients with influenza A/H1N1. Materials and methods. Fifty-seven isolates from 43 patients with pneu- monia, which complicated pandemic influenza A/ H1N1 and treated in Chita city clinical hospital No.1 as well as 32 immunograms were retrospectively studied. Comparison of immunologic and epidemiologic status of patients with influenza A/ H1N1 complicated by pneumonia was performed. Data on dynamics of epidemic process and outcomes are presented. Results. It was established that severe course of influenza A/H1N1 complicated by pneumonia characterized by relative lymphopenia, of CD4 + cells, and 1.7-fold decrease of CD8 + lymphocytes. Degree of changes in parameters of cellular immunity corresponded to severity of pneumonia. Bacteriologic tests showed that there was contamination of respiratory tract of patients with influenza A/H1N1 by opportunistic microflora, predominantly by Streptococcus mitis. Conclusion. In patients with severe form of influenza A/H1N1, which complicated by development of pneumonia, depression of T-cell immunity with contamination of respiratory tract by opportunistic microflora and prolonged course of pathologic process was observed.

influenza A/H1N1, pneumonia, immu- nity, bacteriological monitoring