IMPROVEMENT OF PERTUSSIS DIAGNOSTICS IN ADULTS WITH PROLONGED COUGH


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Abstract

Aim. To study clinical and laboratory data and levels of IgG, IgG1, IgG2, IgG3, IgG4, IgA and IgM to Bordetella pertussis complex of antigens in adults with prolonged cough. Materials and methods. Antibody levels to Bordetella pertussis complex of antigens were measured by solid phase immunoenzyme assay. Clinical and laboratory methods included CBC, chest X-ray, measurement of respiratory function, allergologic tests. Results. In 16 out of 75 studied patients (21%) serological signs that are characteristic for current pertussis infection (increased levels of specific IgG and IgA as well as IgG1 — IgG3 — IgG2 — IgG4 type of distribution of specific IgG subclasses) were observed. Clinical and laboratory parameters — course of disease, characteristics of cough, results of CBC — corresponded to diagnosis of pertussis. In other studied patients levels of specific antibodies did not differ from levels observed in healthy persons and observed clinical signs corresponded to other respiratory diseases. Conclusion. Obtained results prove the high incidence of pertussis in adults, its essential importance as etiologic factor of prolonged cough and high informative value of serologic tests.

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СОВЕРШЕНСТВОВАНИЕ ДИАГНОСТИКИ КОКЛЮША У ВЗРОСЛЫХ С ДЛИТЕЛЬНЫМ КАШЛЕМ
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About the authors

E. M Zaytsev

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

I. K Mazurova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

M. S Petrova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

L. I Krasnoproshina

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

T. I Astakhova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

E. N Laur

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

O. A Komarova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

N. S Zakharova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

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Copyright (c) 2009 Zaytsev E.M., Mazurova I.K., Petrova M.S., Krasnoproshina L.I., Astakhova T.I., Laur E.N., Komarova O.A., Zakharova N.S.

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