SOME FEATURES OF MANIFESTATIONS OF EPIDEMIC PROCESS DURING ACUTE INTESTINAL INFECTIONS IN MOSCOW

Aim. Study manifestations of epidemic process during acute intestinal infections to establish reasons of low effectiveness of the prophylactic measures carried out and evaluation of the role of rotavirus infection in general disease structure ofintestinal infections ofunknown etiology. Materials and methods. Data on morbidity of acute intestinal infections of population of Moscow were analyzed. Hospitalized patients with acute intestinal infections were examined using real-time PCR method test-systems of laboratory of molecular virology of Mechnikov RIVS with subsequent typing. Results. Evaluation of multi-year manifestations of epidemic process of morbidity of acute intestinal infections in Moscow has shown, that the cumulative morbidity does not have a tendency of reduction, because the proportion of infections with undeciphered etiological factors is almost 80% of the total aggregate morbidity. The proportion of rotavirus infection in total morbidity of AII of established etiology increased from 53.2 in 2004 to 82.6% in 2014. Morbidity in children with rotavirus infection is 6 times higher than morbidity in adults. Conclusion. The results obtained give evidence on the necessity of carrying out specific prophylaxis against viral intestine infection, mostly of rotavirus and norovirus infections. The highest effect should have been expected from use of a bi-vaccine, development of which seems quite an actual problem.

rotavirus infection, norovirus infection, real-time PCR