EFFECT OF COMBINED ADMINISTRATION OF BILE DUCT DECOMPRESSION AND LACTULOSEIN MECHANICAL JAUNDICE

Aim. Study the state of intestine microecology in patients with obstructive jaundice after decompression
of bile ducts and administration of lactulose. Materials and methods. 58 patients of different gender and age
who were under treatment in the 13th surgical department of City Clinical Hospital No. 7 due to obstructive
jaundice were examined. Evaluation of lactulose administration was carried out in a blinded randomized
study. The patients were divided into 2 groups of 29 individuals each: (1) patients who had undergone surgery
without administration of lactulose (control) and (2) patients who had received immediately after decompression
of bile ducts 30 ml of lactulose for 1 week (comparison group). Feces samples were obtained with a
weekly interval for bacteriological study for dysbacteriosis. Results. Based on the results of bacteriological
analysis of feces in all the 58 patients with mechanical jaundice disorders of intestine microecology of various
severity degrees were detected. In the patient group who had received lactulose for 7 days after the decompression
of bile ducts a tendency for an increase of population level of bifidobacteria and lactobacilli and a decrease
of quantity of opportunistic microorganisms of various taxonomical groups was noted. Conclusion.
Administration of lactulose to patients at 30 ml dose per day for 7 days positively affected the state of microbiocenosis
of colon towards its normalization.

mechanical jaundice, intestine dysbacteriosis, decompression, biliary tracts, lactulose, therapeutic effect