Email this article RENAL CALCULUS MICROFLORA IN UROLITHIASIS AND SEARCH FOR AGENTS OF CONTROL OF BIOFILMS FORMED BY UROPATHOGENIC BACTERIA
- Authors: Tolordava ER1, Tiganova IG1, Alekseeva NV1, Stepanova TV1, Terekhov AA1, Egamberdiev DK1, Mulabaev NS1, Shevlyagina NV1, Didenko LV1, Romanova Y.M1
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Affiliations:
- Issue: Vol 89, No 4 (2012)
- Pages: 56-62
- Section: Articles
- Submitted: 09.06.2023
- Published: 15.12.2012
- URL: https://microbiol.crie.ru/jour/article/view/13716
- ID: 13716
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Abstract
and development of biofilm model by isolates in vitro on sterile calculi of various chemical
composition. Materials and methods. Bacterial spectra of microflora of renal calculus lavages were
studied, isolated pure cultures were identified up to species. Comparisons of urine microflora
obtained before operation in patients with urolithiasis with microflora of removed renal calculi
were carried out. Results. Urease activity and genes coding pathogenicity factors were detected,
and the ability to form biofilms by isolates was studied. Model of formation of biofilms in vitro on
sterile renal calculi was developed and candidate agents reducing the biofilm forming ability were
tested. Conclusion. Uropathogenic microorganisms infecting renal calculi and forming biofilms
on them not only support chronic infection by increased resistance to therapy but also facilitate
novel lithogenesis.
Keywords
About the authors
E R Tolordava
I G Tiganova
N V Alekseeva
T V Stepanova
A A Terekhov
D K Egamberdiev
N S Mulabaev
N V Shevlyagina
L V Didenko
Yu M Romanova
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