IMMUNITY TO POLIOVIRUS AFTER VACCINATION OF CHILDREN WITH TYPE 1 DIABETES MELLITUS AND RHEUMATIC DISEASES


Cite item

Full Text

Abstract

Aim . To assess immunization coverage against poliomyelitis and level of immunity postvaccination in children with type 1 diabetes mellitus (DM1) and rheumatic diseases. Materials and methods . Vaccination status of 299 children with DM1 and 136 children with rheumatic diseases was determined. Serologic test using neutralization reaction was performed in 31 children with DM1 and 29 children with rheumatic diseases. Three hundred and eighty healthy children aged 3 — 14 years were included in the control group. All children previously received oral poliovirus vaccine. Results . During postimmunization period decompensations of main disease in children w ith DM1 and rheumatic diseases were not observed. There were no seronegati ve children to all poliov irus types revealed. Proportion of children with DM1 and rheumatic diseases seronegative to two serotypes was 12.9% and 13.8% respectively. Proportion of children with DM1 seropositive to all 3 serotypes was 54.8% that is lower than in general population (p<0.01), whereas in children with rheumatic diseases this proportion was 75.8%. In children with DM1 real proportion of immune subjects was normal — 94.9% and 82.0% for poliovirus types 1 and 2 respectively, whereas the same proportion for poliovirus type 3 was 49.7%. In children with rheumatic diseases real proportion of immune subjects was normal for poliovirus types 1 and 2, and was 72.4% for poliovirus type 3. Conclusion . Algorithms of examination of patients with DM1 and rheumatic diseases, which allow to purposefully perform serologic evaluation as well as recommendations about additional immunization against poliomyelitis, were developed.

Full Text

НАПРЯЖЕННОСТЬ ПОСТВАКЦИНАЛЬНОГО ИММУНИТЕТА К ВИРУСУ ПОЛИОМИЕЛИТА У ДЕТЕЙ С САХАРНЫМ ДИАБЕТОМ 1 ТИПА И РЕВМАТИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ
×

About the authors

A. A Tarasova

Nizhny Novgorod Regional Children’s Clinical Hospital

O. N Knyagina

Administration of Federal Service for Surveillance for Protection of Consumers Rights and Human Welfare in Nizhny Novgorod region

N. A Kalashnikova

Center of Hygiene and Epidemiology in Nizhny Novgorod region

M. P Kostinov

Mechnikov Research Institute of Vaccines and Sera, Moscow

V. L Erukhimov

«Corporation Intel» Laboratory, Nizhny Novgorod, Russia

References

  1. Баранов А.А., Алексеева Е.И., Шувалова М.П. и др. Проблемы ревматических болезней у детей в Российской Федерации. Росс. педиатр. журн. 2003, 5: 4-10.
  2. Иванова О.Е., Романенкова Н.И., Еремеева Т.П. и др. Риск развития случаев вялого паралича и вакцинассоциированного полиомиелита в закрытых детских коллективах — домах ребенка и детских лечебных стационарах. Эпидемиол. вакцинопроф. 2005, 1 (20): 14-18.
  3. Смирнов В.В. Резистентность организма и роль инфекции в патогенезе и клинике сахарного диабета у детей. Автореф. дис. д-ра мед. наук. М., 1992.
  4. Руководство по вирусологическим исследованиям при полиомиелите. WHO/EPI/POLIO/ 90/l/.
  5. Breiman L., Friedman J., Olshen R., Stone C. Classification and regression trees. Wadsworth, Belmon, 1984.
  6. Chen R.T., Pless R., Destefano F. Epidemiology of autoimmune reactions induced by vaccination. J. Аutoimmunity. 2001, 16 (3): 309-318.
  7. Hummel M., Fuchtenbusch M., Schenker M. et al. No major assotiation of breast-funding, vaccination and childhood viral diseases with early islet autoimmunity in the German BABY-DIAB study. Diabetes Care. 2000, 23: 969-974.
  8. Hviid A., Stellfeld M., Wohltahrt J. et al. Routine childhood vaccinations did not increase the risk of incident type 1 diabetes in Danish children. N. Engl. J. Med. 2004, 350: 1398-1404.
  9. Hyoty H., Taylor K.W. The role of viruses in human diabetes. Diabetologia. 2002, 45 (910): 1353-1361.
  10. Jee Y.M., Cheon D.S., Kim K.S. et al. A seroprevalence study of poliovirus antibody among primary schoolchildren in Korea. Epidemiol. Infect. 2004, 132 (2): 351-355.
  11. Maillefert J.F., Tonolli-Serabian J., Cherasse A. et al. A r thritis following combined vaccine against diphtheria, poliomyelitis and tetanus toxoid. Clin. Exp. Rheumatol. 2000, 18 (2): 255-256.
  12. Salminen K.K., Vuorinen T., Oikarinen S.et al. Isolation of enterovirus strains from children with preclinical Type 1 diabetes. Diabet. Med. 2004, 21 (2): 156-164.
  13. Viskari H., Ludvigsson J., Uibo R. et al. Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project. J. Med. Virol. 2004, 72 (4): 610-617.
  14. Wahlberg J., Fredriksson J., Vaarala O. et al. Vaccination may induce diabetes—related autoantibodies in one-year-old children. Ann. N.Y. Acad. Sci. 2003, 1005: 404-408.
  15. Zingg W. Does vaccination cause disease? Ther Umsch. 2005, 62 (10): 665-674.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Tarasova A.A., Knyagina O.N., Kalashnikova N.A., Kostinov M.P., Erukhimov V.L.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС77-75442 от 01.04.2019 г.