IMMUNITY TO POLIOVIRUS AFTER VACCINATION OF CHILDREN WITH TYPE 1 DIABETES MELLITUS AND RHEUMATIC DISEASES

  • Authors: Tarasova A.A1, Knyagina O.N2, Kalashnikova N.A3, Kostinov M.P4, Erukhimov V.L5
  • Affiliations:
    1. Nizhny Novgorod Regional Children’s Clinical Hospital
    2. Administration of Federal Service for Surveillance for Protection of Consumers Rights and Human Welfare in Nizhny Novgorod region
    3. Center of Hygiene and Epidemiology in Nizhny Novgorod region
    4. Mechnikov Research Institute of Vaccines and Sera, Moscow
    5. «Corporation Intel» Laboratory, Nizhny Novgorod, Russia
  • Issue: Vol 86, No 5 (2009)
  • Pages: 52-57
  • Section: Articles
  • Submitted: 09.06.2023
  • Published: 15.10.2009
  • URL: https://microbiol.crie.ru/jour/article/view/13309
  • ID: 13309

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Abstract

Aim . To assess immunization coverage against poliomyelitis and level of immunity postvaccination in children with type 1 diabetes mellitus (DM1) and rheumatic diseases. Materials and methods . Vaccination status of 299 children with DM1 and 136 children with rheumatic diseases was determined. Serologic test using neutralization reaction was performed in 31 children with DM1 and 29 children with rheumatic diseases. Three hundred and eighty healthy children aged 3 — 14 years were included in the control group. All children previously received oral poliovirus vaccine. Results . During postimmunization period decompensations of main disease in children w ith DM1 and rheumatic diseases were not observed. There were no seronegati ve children to all poliov irus types revealed. Proportion of children with DM1 and rheumatic diseases seronegative to two serotypes was 12.9% and 13.8% respectively. Proportion of children with DM1 seropositive to all 3 serotypes was 54.8% that is lower than in general population (p<0.01), whereas in children with rheumatic diseases this proportion was 75.8%. In children with DM1 real proportion of immune subjects was normal — 94.9% and 82.0% for poliovirus types 1 and 2 respectively, whereas the same proportion for poliovirus type 3 was 49.7%. In children with rheumatic diseases real proportion of immune subjects was normal for poliovirus types 1 and 2, and was 72.4% for poliovirus type 3. Conclusion . Algorithms of examination of patients with DM1 and rheumatic diseases, which allow to purposefully perform serologic evaluation as well as recommendations about additional immunization against poliomyelitis, were developed.

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НАПРЯЖЕННОСТЬ ПОСТВАКЦИНАЛЬНОГО ИММУНИТЕТА К ВИРУСУ ПОЛИОМИЕЛИТА У ДЕТЕЙ С САХАРНЫМ ДИАБЕТОМ 1 ТИПА И РЕВМАТИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ
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About the authors

A. A Tarasova

Nizhny Novgorod Regional Children’s Clinical Hospital

O. N Knyagina

Administration of Federal Service for Surveillance for Protection of Consumers Rights and Human Welfare in Nizhny Novgorod region

N. A Kalashnikova

Center of Hygiene and Epidemiology in Nizhny Novgorod region

M. P Kostinov

Mechnikov Research Institute of Vaccines and Sera, Moscow

V. L Erukhimov

«Corporation Intel» Laboratory, Nizhny Novgorod, Russia

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Copyright (c) 2009 Tarasova A.A., Knyagina O.N., Kalashnikova N.A., Kostinov M.P., Erukhimov V.L.

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