Isakova-Sivak Irina, PhD, D. Sc. (Biology), Corresponding Member of the Russian Academy of Sciences
Head of the laboratory of immunology and prevention of viral diseases, Department of Virology named after A.A. Smorodintsev of the Institute of Experimental Medicine; leading researcher of the St. Luke's Clinical Hospital (St. Petersburg).
Scopus h-index — 22.
Web of Science h-index — 19
SCOPUS AuthorID, ORCID ID, Web of Science ResearcherID, ResearchGate, RSCI
Biography
2004 — graduated from the Department of Biophysics, Faculty of Physics and Mechanics, St. Petersburg State Polytechnic University. 2002-2017 — Research Laboratory Assistant, Research Associate, Senior Researcher, Leading Researcher of the Department of Virology named after A.A. Smorodintsev, Institute of Experimental Medicine. Since 2017 — Head of the Laboratory of Immunology and Prevention of Viral Infections of the A.A. Smorodintsev Department of Virology of the Institute of Experimental Medicine. In 2007, defended PhD thesis. From 2007 to 2009 — guest researcher at the Centers for Disease Control and Prevention (CDC, Atlanta, USA), where she conducted research related to the use of genetic engineering methods for the development of vaccines against potentially pandemic avian influenza viruses. In 2018 — defended her Doctorate thesis, topic: “Molecular genetic approaches for the optimization of live attenuated influenza vaccines”. In 2022 — elected Corresponding Member of the Russian Academy of Sciences from the Department of Medical Sciences. Since 2023 — leading researcher at St. Luke's Clinical Hospital in St. Petersburg.
Research interests
Study of humoral and T-cell immune responses at systemic and local levels after viral infections and vaccination with antiviral vaccines. Design of vaccine strains against potentially pandemic human and avian influenza viruses, development of broadly protective influenza vaccines (universal influenza vaccine) and recombinant viral vectored vaccines providing combined protection against various pathogens of respiratory viral and bacterial infections. Study of pathogenesis of respiratory viral infections and search for effective antiviral compounds and biomolecules.
Keywords
Influenza virus, influenza vaccines, genetic engineering, infectious immunology, pathogenesis of viral infections, vector vaccines, preclinical studies of vaccines, clinical studies of vaccines, molecular medicine, medical biotechnology, acute respiratory viral infections (ARVI), SARS-CoV-2, bacterial infections, Streptococcus pneumoniae.
The author of more than 150 scientific papers and 26 patents for invention.
Under her supervision, 2 PhD theses were defended.
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