Aleksandr L. Gintsburg, D. Sci. (Biology), Professor, Full Member of the Russian Academy of Sciences.
Director of the N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology; Head of the Department of infectology and virology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Winner of the Russian Government award. Awarded the medal of P. Ehrlich.
Web of Science h-index — 16
SCOPUS AuthorID, ORCID ID, Mendeley, Elibrary, ResearchGate
Biography
In 1974, he graduated from the Biology and soil faculty of Moscow State University.
Since 1982 — works at the National Research Center of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, Director (since 1997).
Since 2000 — Head of the Department of infectology of the Medical and preventive faculty of postgraduate professional education of the I.M. Sechenov First Moscow State Medical University (Sechenov University).
In 2000, he was elected a corresponding member, and in 2004 — a Full Member of the Russian Academy of Sciences.
In 2013, he became an academician of the Russian Academy of Sciences (within the framework of joining the RAMS and RASKHN to the RAS).
Research interests and main scientific achievements:
- creation of a scientific direction in infectious pathology, engaged in the study of molecular mechanisms of interaction between pathogenic bacteria and the human body;
- theoretical and experimental substantiation of the position that genes of pathogenicity factors are part of mobile genetic elements, which makes it possible to quickly adapt pathogenic bacteria to sharply changing conditions of existence in the environment or in the host organism;
- identification of mechanisms for the formation of epidemically significant strains isolated from both natural foci and outbreaks of hospital infections, based on the study of infectious disease pathogens using modern genomic technologies;
- creation of diagnostic test systems for identification of infectious disease pathogens based on polymerase chain reaction.
- creation of the concept of resting (uncultivated) state of pathogenic bacteria, allowing pathogens of particularly dangerous infections to form endemic natural foci;
- justification of the need for molecular genetic monitoring of pathogens of particularly dangerous infectious diseases;
- study of the global regulatory system of bacterial gene activity depending on population density («Quorum sensing»)
- study of two main mechanisms of long-term persistence of pathogenic bacteria and chronization of the infectious process: 1) modulation by pathogenic bacteria of the signaling processes of eukaryotic host cells (anti-apoptotic activity of bacteria) and 2) the ability of bacteria to form biofilms;
- development of new approaches to the treatment of chronic infectious diseases, based on the creation of anti-pathogenic drugs, which, unlike antimicrobial, causing death or inhibition of bacterial growth, would have the ability to reduce or block the virulence of bacteria, resulting in the infection could cope with the immune system of the body.
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