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Chronic generalized periodontitis (CGP) is a disease of periodontium tissues supporting tooth induced by bacteria, that is characterized by the presence of processes of inflammation with destruction ofbone tissue. The knowledge of molecular mechanisms of CGP pathogenesis facilitates creation of the most effective methods of therapy of this disease. Bacterial infection is a primary factor in periodontitis etiology, however is not sufficient for its start and subsequent development. It is known, that bacterial factors induce a local inflammation reaction and activate the system of innate immunity through activation of Toll-like receptors (TLR), located on the surface of resident cells and leukocytes. Activation of these cells results in production of pro-inflammatory cytokines and recruitment of phagocytes and lymphocytes into the inflammation zone. In review we examined the known data regarding factors of immune protection of periodontium including cell populations and cytokines, as well as mechanisms of tissue destruction, that support the tooth. Perspectives of therapy are also discussed.

About the authors

L. V. Gankovskaya

Pirogov Russian National Research Medical University

Author for correspondence.
Russian Federation

N. M. Khelminskaya

Pirogov Russian National Research Medical University

Russian Federation

E. A. Molchanova

Pirogov Russian National Research Medical University

Russian Federation

O. A. Svitich

Mechnikov Research Institute of Vaccines and Sera

Russian Federation


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Copyright (c) 2016 Gankovskaya L.V., Khelminskaya N.M., Molchanova E.A., Svitich O.A.

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