DEPENDENCE OF DETECTION OF MARKERS OF OPPORTUNISTIC INFECTIONS FROM ADHERENCE TO ANTIRETROVIRAL THERAPY IN CHILDREN BORN BY HIV-INFECTED MATTERS

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Abstract

Aim. To study the dependence of detection of markers of opportunistic infections from afherence to antiretroviral therapy in children born to HIV-infected mothers on the example of herpesvirus infectionsand pneumocystis. Materials and methods. Samples of biological materials (blood serum and blood cells) of 66 children with HIV infection aged 1 month to 15 years old were treated in Children’s Boxed Department of Children’s Hospital No. 2 with diagnoses «incomplete HIV test» (children from the age of one month to one and a half years) and «HIV infection». To determine IgM and IgG to herpesviruses and pneumocyst, the method of enzyme immunoassay was used; indirect immunofluorescence reaction for the detection of herpesviruses and their antigens in the blood, early antigens and virus reproduction were determined using a rapid culture method. Results. 56.0% of the surveyed children received complete antiretroviral therapy, in 16,7% of cases they were not complete, and 27,3% of children did not fully adhere to ARVT. Despite the fact that 100% of children with an incomplete diagnosis of HIV infection were covered by ARVT due to the use of chemotherapy drugs by their mothers during pregnancy, they still had markers of both active and latent forms of herpesvirus infections and pneumocystis. In children with confirmed HIV infection living both in social institutions and in families, the markers of opportunistic infections were more often diagnosed in patients receiving ARVT in full and not in full volume than in children who did not have it. Conclusion. Identification of markers of active forms of herpesvirus infections and pneumocystis in HIV-positive children not receiving ARV is the basis for its immediate appointment.

About the authors

T. N. Rybalkina

Gamaleya National Research Centre of Epidemiology and Microbiology

Author for correspondence.
Email: noemail@neicon.ru
Россия

N. V. Karazhas

Gamaleya National Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Россия

P. A. Savinkov

Gamaleya National Research Centre of Epidemiology and Microbiology, Infectious Clinical Hospital No. 2

Email: noemail@neicon.ru
Россия

R. E. Boshyan

Gamaleya National Research Centre of Epidemiology and Microbiology, Sechenov First Moscow State Medical University

Email: noemail@neicon.ru
Россия

M. Yu. Lysenkova

Gamaleya National Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Россия

M. N. Kornienko

Gamaleya National Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Россия

E. M. Burmistrov

Gamaleya National Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Россия

P. A. Veselovsky

Gamaleya National Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Россия

I. A. Soldatova

Infectious Clinical Hospital No. 2

Email: noemail@neicon.ru
Россия

References

  1. Кибец Е.В., Коваленко Т.А., Евдокимова И.А. Приверженность к АРВ-терапии у ВИЧ-положительных детей на разных возрастных этапах. М., Спецкнига, 2014.
  2. Кремер Н.Ш. Теория вероятностей и математическая статистика. Проверка гипотез о равенстве долей признака в двух и более совокупностях. 2004.
  3. Латышева И.Б., Воронин Е.Е. ВИЧ-инфекция у женщин в РФ. Актуальные вопросы ВИЧ-инфекции. СПб, Человек и его здоровье, 2016.

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Copyright (c) 2018 Rybalkina T.N., Karazhas N.V., Savinkov P.A., Boshyan R.E., Lysenkova M.Y., Kornienko M.N., Burmistrov E.M., Veselovsky P.A., Soldatova I.A.

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