EPIDEMIOLOGICAL STUDY OF MAIN CLONES DISTRIBUTION GENOTYPE BEIJING OF MYCOBACTERIUM TUBERCULOSIS WITHIN IRKUTSK REGION

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Abstract

Aim. To estimate the dynamics changes in the population structure of the tuberculosis (ТВ) pathogen in the Irkutsk region by comparison of genotypes of M. tuberculosis from patients of different age groups. Materials and methods. 588 epidemiologically unrelated strains of M. tuberculosis isolates from 567 ТВ patients were characterized using 24-locus MIRU-VNTR typing. 160 strains belonged to patients of different age groups. 59 strains were isolated from the «young» people with ТВ who were bom after 1990 and 101 isolates from people who were born before 1955. Results. Two-thirds of the samples (427/567) were genotype Beijing with the dominance of two subtypes belonging to the modem epidemic clonal complexes CC1 and CC2. The high level of clustering profiles of CC1 and CC2 genotype Beijing in «older» and «young» patients in the Irkutsk region indicates the presence and active transmission of epidemic CC1 and CC2 subtypes over the past fifty years.

About the authors

S. N. Zhdanova

Scientific Center of Family Health Problems and Human Reproduction

Author for correspondence.
Russian Federation

O. B. Ogarkov

Scientific Center of Family Health Problems and Human Reproduction; lrkutsk State Medical Academy of Postgraduate Education; Irkutsk State University

Russian Federation

V. V. Sinkov

Scientific Center of Family Health Problems and Human Reproduction

Russian Federation

P. A. Khromova

Scientific Center of Family Health Problems and Human Reproduction

Russian Federation

E. A. Orlova

Scientific Center of Family Health Problems and Human Reproduction

Russian Federation

M. E. Koscheev

Irkutsk Regional Clinical Tuberculosis Hospital

Russian Federation

E. D. Savilov

Scientific Center of Family Health Problems and Human Reproduction; lrkutsk State Medical Academy of Postgraduate Education

Russian Federation

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Copyright (c) 2017 Zhdanova S.N., Ogarkov O.B., Sinkov V.V., Khromova P.A., Orlova E.A., Koscheev M.E., Savilov E.D.

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