Email this article EFFECT OF LIPOPOLYSACCHARIDE OF ESCHERICHIA COLI ON PHAGOCYTE AND METABOLIC ACTIVITY OF MICE BLOOD NEUTROPHILS WITH INDUCED IMMUNE DEFICIENCY
- Authors: Mavzyutov A.R.1, Knyazeva O.A.1, Garafutdinov R.R.2, Gabdrakhmanova A.R.3
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Affiliations:
- Bashkiria State Medical University
- Institute of Biochemistry and Genetics
- Bashkiria State Medical University, Bashkiria State University
- Issue: Vol 94, No 3 (2017)
- Pages: 84-90
- Section: ORIGINAL RESEARCHES
- URL: https://microbiol.crie.ru/jour/article/view/165
- DOI: https://doi.org/10.36233/0372-9311-2017-3-84-90
- ID: 165
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Abstract
Aim. Experimental evaluation of effect of E. coli LPS fractions on phagocyte and metabolic activity of blood neutrophils of laboratory mice with induced immune deficiency. Materials and methods. Phagocyte activity was evaluated by phagocyte number (PN), phagocyte index (PI) and integral phagocyte index (IPI), intensity of metabolism and energetic processes of enzyme systems - by test of tetrazolium nitro blue (TNB), mean cytochemical coefficient (MCC) in spontaneous and induced tests and stimulation index (SI). Results. LPS-3 substance administration into mice with secondary immune deficiency has resulted in a significantly highest increase of PN (15.8%), IPI (17.7%), TNB-IN (10.3%), cytochemical coefficients MCC-IN (u.) and IS (u.) - 14.8 and 10.9%, respectively, compared with the parameters of immune deficient mice that had received licopid. Conclusion. Some fractions of E. coli M17 polysaccharide have immune stimulating activity.
About the authors
A. R. Mavzyutov
Bashkiria State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
O. A. Knyazeva
Bashkiria State Medical University
Email: noemail@neicon.ru
Russian Federation
R. R. Garafutdinov
Institute of Biochemistry and Genetics
Email: noemail@neicon.ru
Russian Federation
A. R. Gabdrakhmanova
Bashkiria State Medical University, Bashkiria State University
Email: noemail@neicon.ru
Russian Federation
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