ROLE OF microRNA IN REGULATION OF INNATE IMMUNITY MECHANISMS


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Abstract

New class of regulatory molecules - microRNA - is of special interest now. Large amount of data about function of these molecules in immune response regulation is accumulated. Functions of several microRNA molecules (miRNA-146, miRNA-155, miRNA-223) contributing to such mechanisms of innate immunity regulation as transmission of signals from receptors, maturation, differentiation and proliferation of innate immunity cells are described in this review. It is necessary to underline the perspective of these molecules for development of drugs for correction of innate immunity abnormalities.

About the authors

L. V Kovalchuk

Russian State Medical University, Moscow, Russia

L. V Gankovskaya

Russian State Medical University, Moscow, Russia

E. A Akimova

Russian State Medical University, Moscow, Russia

References

  1. Ковальчук Л.В. Врожденные компоненты иммунитета: Toll-подобные рецепторы в норме и иммунной паталогии. Журн. микробил. 2005, 4: 96-104.
  2. Akira S., Uematsu S., Takeuchi O. et al. Pathogen recognition and innate immunity. Cell. 2006, 124 (4): 783-801.
  3. Alvarez-Garcia I., Miska E.A. MicroRNA functions in animal development and human disease. Development. 2005, 132: 4653-4662.
  4. Cai X., Lu S., Zhang Z. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc. Natl. Acad. Sci. USA. 2005, 12; 102 (15): 5570 - 5575.
  5. Carthew R.W. Gene regulation by microRNAs. Genet. Dev. 2006, 16: 203-208.
  6. Cullen B.R. Transcription and processing of human microRNA precursors. Mol. Cell. 2004, 16: 861-865.
  7. Eddy S.R. Non-coding RNA genes and the modern RNA world. Nat. Rev. Genet. 2001, 2 (12): 919-929.
  8. Eis P.S., Tam W., Sun L. et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. USA. 2005, 102: 3627-3632.
  9. Engels B.M., Hutvagner G. Principles and effects of microRNAmediated post-transcriptional gene regulation. Oncogene. 2006, 25: 6163-6169.
  10. Fazi F., Rosa A., Fatica A. et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI A and C/EBPalpha regulates human granulopoiesis. Cell. 2005, 123: 819-831.
  11. Fukao T., Fukuda Y., Kiga K. et al. An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Ibid. 2007, 129 (3): 617-631.
  12. Iwasaki A., Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004, 5 (10): 987-995.
  13. Johnnidis J.B., Harris M.H., Wheeler R.T. et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature. 2008, 451: 1125-1129.
  14. Lagos-Quintana M., Rauhut R., Lendeckel W. et al. Identification of novel genes coding for small expressed RNAs. Science. 2001, 26; 294 (5543): 853-858.
  15. Lai E.C. Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat. Genet. 2002, 30: 363-364.
  16. Lee Y., Ahn C., Han J. et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003, 425: 415-419.
  17. Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993, 75: 843-854.
  18. Lewis B.P., Burge C.B., Bartel D.P. et al. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Ibid. 2005, 120: 15-20.
  19. Liew F.Y., Xu D., Brint E.K. et al. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 2005, 5 (6): 446-458.
  20. Mark A. Lindsay. MicroRNAs and the immune response. Trends Immunol. 2008, 29 (7): 343-351.
  21. Moschos S.A., Williams A.E., Perry M.M. et al. Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide- induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics. 2007, 17: 8.
  22. O’Connell R.M., Rao D.S., Chaudhuri A.A. et al. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J. Exp. Med. 2008, 205: 585-594.
  23. O’Connell R.M., Taganov K.D., Boldin M.P. et al. MicroRNA-155 is induced during the macrophage inflammatory response. Proc. Natl. Acad. Sci. USA. 2007, 104: 1604-1609.
  24. Perry M.M. Moschos S.A., Williams A.E. et al. Rapid changes in microRNA-146a expression negatively regulate the interleukin-1b induced inflammatory response in human lung alveolar epithelial cells. J.Immunol. 2008, 180: 5689-5698.
  25. Rodriguez A., Griffiths-Jones S., Ashurst J.L. et al. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004, 14: 1902-1910.
  26. Rodriguez A., Vigorito E., Clare S. et al. Requirement of bic/microRNA-155 for normal immune function. Science. 2007, 316: 608-611.
  27. Taganov K.D., Boldin M.P., Chang K.J. еt al. NFkappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA. 2006, 103: 12481-12486.
  28. Tili E., Michaille J.J., Cimino A. et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/tnf-{alpha} stimulation and their possible roles in regulating the response to endotoxin shock. J.Immunol. 2007, 179: 5082-5089.
  29. Yi R., Qin Y., Macara I.G. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003, 17: 3011-3016.

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Copyright (c) 2009 Kovalchuk L.V., Gankovskaya L.V., Akimova E.A.

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