Email this article INTESTINE DYSBIOSIS AND ATOPIC DERMATITIS IN YOUNG CHILDREN
- Authors: Aleshukina AV1
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Affiliations:
- Issue: Vol 89, No 5 (2012)
- Pages: 84-89
- Section: Articles
- Submitted: 13.06.2023
- Published: 15.10.2012
- URL: https://microbiol.crie.ru/jour/article/view/14222
- ID: 14222
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Abstract
Aim. Study the intensity of anti-endotoxin response in intestine of children with atopical dermatitis and
intestine dysbioses. Materials and methods. 110 children with atopic dermatitis of various localization were
examined in an outpatient setting. Besides detection of dysbiotic disorders in intestine by using bacteriological
seeding on differential-diagnostic media and criteria of evaluation of degree of micro-ecological
disorders according to Industry standard of Ministry of Health of Russian Federation «rotocol of patient
management. Intestine dysbacteriosis»(2003), content of antibodies against LPS of enterobacteria belonging
to various immunoglobulin classes (IgG, IgA, IgM, IgE) by EIA was studied in coprofiltrates. Results. An
increase of content of various immunoglobulins, specific LPS of enterobacteria that depended on the degree
of intensity of dysbiotic disorders was detected in children. Allergization in children correlated with an increase
of level of anti-endotoxin IgE and IgM (0.8±.2) and decrease of IgA content in intestine (-0.8±.2). The
higher the level of serum anti-LPS antibodies, the more frequently allergic manifestation occur in children.
Conclusion. Correlation between the level of anti-endotoxin serum IgE and frequency of occurrence of allergic
manifestations in children was shown.
intestine dysbioses. Materials and methods. 110 children with atopic dermatitis of various localization were
examined in an outpatient setting. Besides detection of dysbiotic disorders in intestine by using bacteriological
seeding on differential-diagnostic media and criteria of evaluation of degree of micro-ecological
disorders according to Industry standard of Ministry of Health of Russian Federation «rotocol of patient
management. Intestine dysbacteriosis»(2003), content of antibodies against LPS of enterobacteria belonging
to various immunoglobulin classes (IgG, IgA, IgM, IgE) by EIA was studied in coprofiltrates. Results. An
increase of content of various immunoglobulins, specific LPS of enterobacteria that depended on the degree
of intensity of dysbiotic disorders was detected in children. Allergization in children correlated with an increase
of level of anti-endotoxin IgE and IgM (0.8±.2) and decrease of IgA content in intestine (-0.8±.2). The
higher the level of serum anti-LPS antibodies, the more frequently allergic manifestation occur in children.
Conclusion. Correlation between the level of anti-endotoxin serum IgE and frequency of occurrence of allergic
manifestations in children was shown.
References
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