ANALYSIS OF POPULATION IMMUNITY OF RESIDENTS OF RUSSIAN FEDERATION REGIONS AGAINST SEASONAL AND HIGHLY PATHOGENIC STRAINS OF INFLUENZA VIRUS


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Abstract

Aim. Determine the level of antibodies against socially significant types/serotypes of influenza virus in sera of individuals residing in various regions of Russia. Materials and methods. 1525 samples of blood sera collected in August-December 2013 in 8 regions of Russian Federation were studied in hemagglutination inhibition reaction (HAI) with antigens obtained from A/ California/07/09 (H1N1)pdm09, A/Victoria/361/2011(H3N2), B/Brisbane/60/2008 (Victoria line), B/Massachusetts/2/2012 (Yamagata line), A/Commongull/Chany/2006 (H5N1), А/ Anhui/01/2013 (H7N9) influenza virus strains. Results. None of the blood sera samples had significant HAI titers against A/H5 and A/H7 antigens. Of all the 1525 samples, 788 (52%) were positive with A(H1N1)pdm09 antigen; 734 (48%) reacted with A(H3N2) antigen; 1010 (66%) samples were positive with B/Victoria antigen and 602 (39%) samples were positive with B/Yamagata antigen. Conclusion. Healthcare institutions should pay attention to the correction of population immunity profile in regions for the reduction of social-economic losses from seasonal influenza epidemics.

About the authors

T. N Ilicheva

State Scientific Centre «Vector», Koltsovo, Novosibirsk Region, Russia

A. G Durymanov

State Scientific Centre «Vector», Koltsovo, Novosibirsk Region, Russia

O. V Petrova

State Scientific Centre «Vector», Koltsovo, Novosibirsk Region, Russia

A. V Epanchintseva

State Scientific Centre «Vector», Koltsovo, Novosibirsk Region, Russia

Yu. S Chukhrov

Centre of Hygiene and Epidemiology in Kemerovo Region, Kemerovo, Russia

Yu. A Garbuz

Centre of Hygiene and Epidemiology in Khabarovsk Region, Khabarovsk, Russia

I. V Bezgodov

Centre of Hygiene and Epidemiology in Irkutsk Region, Irkutsk, Russia

K. V Bulutov

Centre of Hygiene and Epidemiology in the Republic of Buryatia, Ulan-Ude, Russia

G. S SArkhipov

Centre of Hygiene and Epidemiology in the Republic of Altai, Gorno-Altaysk, Russia

S. S Samarsky

Centre of Hygiene and Epidemiology in Sakahalin Region, Yuzhno-Sakhalinsk, Russia

V. B Ziatdinov

Centre of Hygiene and Epidemiology in the Republic of Tatarstan, Kazan, Russia

V. Yu Ananiev

Centre of Hygiene and Epidemiology in Primorsky Region, Vladivostok, Russia

V. N Mikheev

State Scientific Centre «Vector», Koltsovo, Novosibirsk Region, Russia

A. B Ryzhikov

State Scientific Centre «Vector», Koltsovo, Novosibirsk Region, Russia

References

  1. Курская О.Г., Дурыманов А.Г., Шаршов К.А., Зайковская А.В., Шестопалов А.М., Ильичева Т.Н. Реакция торможения гемагглютинации для ретроспективной диагностики гриппа птиц у млекопитающих. Журн. микробиол. 2009, 5: 75-79.
  2. Многоцелевые серологические обследования и банки эталонных сывороток ВОЗ. Серия техн. докл. ВОЗ, 1972, № 454.
  3. Broberg E., Nicoll A. Amato-Gauci A. et al. Seroprevalence to influenza A(H1N1) 2009 virus - where are we? Clin. Vaccine Immunol. 2011, 18 (8): 1205-1212.
  4. Hannoun C., Megas F., Piercy J. Immunogenicity and protective efficacy of influenza vaccination. Virus Res. 2004, 103: 133-138.
  5. Hirst G.K. The agglutination of red cells by allantoic fluid of chick embryos infected with influenza virus. Science. 1941, 94 (2427): 22-23.
  6. Katz J.M., Hancock K., Xu X. Serologic assays for influenza surveillance, diagnoses and vaccine evaluation. Expert Rev. Anti Infect. Ther. 2011, 9 (6): 669-683.
  7. Riley S., Wu J.T., Leung G.M. Optimizing the dose of prepandemic influenza vaccines to reduce the infection attack rate. PLoS Med. 2007, 4 (6): e218. doi: 10.1371/journal.pmed.0040218.
  8. Salk J.E. Simplified procedure for titrating hemagglutinating capacity of influenza virus and the corresponding antibody. J. Immun. 1944, 49: 87.
  9. WHO. Manual for the laboratory diagnosis and virological surveillance of influenza. WHO, 2011.
  10. http://www.gks.ru/wps/wcm/connect/rosstat_main/rosstat/ru/statistics/publications/catalog/ doc_1140095700094.

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Copyright (c) 2014 Ilicheva T.N., Durymanov A.G., Petrova O.V., Epanchintseva A.V., Chukhrov Y.S., Garbuz Y.A., Bezgodov I.V., Bulutov K.V., SArkhipov G.S., Samarsky S.S., Ziatdinov V.B., Ananiev V.Y., Mikheev V.N., Ryzhikov A.B.

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