PAPILLOMAVIRUS INFECTION: PRINCIPLE CHARACTERISTICS, CLINICAL MANIFESTATIONS, VACCINE PROPHYLAXIS

Cover Page


Cite item

Full Text

Abstract

Papillomaviruses are a large and diverse group of viruses. It includes approximately 200 fully described types that have been detected in humans. Human papilloma viruses (HPV) are etiologic agents during various benign and malignant lesions of mucous membrane and skin epithelium. Very importantly, persistent HPV infection of certain types is a leading cause of carcinoma of uterine cervix, penis, vulva, vagina, anal canal and fauces (including tongue base and tonsils). HPV infection prophylaxis is the best means to control HPV-conditioned diseases, and vaccination, as had been demonstrated, - the most effective method of its prophylaxis. In this paper principle characteristics and clinical manifestations of papillomavirus infection, as well as effectiveness of vaccination against HPV are examined.

About the authors

P. D. Lopukhov

Sechenov First Moscow State Medical University

Author for correspondence.
Russian Federation

N. I. Briko

Sechenov First Moscow State Medical University

Russian Federation

A. A. Khaldin

Moscow Scientific-Practical Centre of Dermatovenerology and Cosmetology

Russian Federation

N. N. Tsapkova

Sechenov First Moscow State Medical University

Russian Federation

O. V. Lupashko

Moscow Scientific-Practical Centre of Dermatovenerology and Cosmetology

Russian Federation

References

  1. Злокачественные новообразования в России в 2013 году (заболеваемость и смертность). Под ред. А.Д.Каприна, В.В.Старинского, Г.В.Петровой. М.: МНИОИ им. П.А. Герцена, 2015.
  2. Ali H., Donovan B., Wand H. et al. Genital warts in young Australians five years into national human papillomavirus vaccination programme: National surveillance data. BMJ. 2013, 346: F2942.
  3. Arbyn M., Dillner J. Review of current knowledge on HPV vaccination: an appendix to the European guidelines for quality assurance in cervical cancer screening. J. Clin. Virol. 2007, 38 (3): 189-197.
  4. Arima Y., Winer R.L., Feng Q.A. et al. Development of genital warts after incident detection of human papillomavirus infection in young men. J. Infect. Dis. 2010, 202: 1181-1184.
  5. Bosch F.X., Broker T.R., Forman D. et al. Comprehensive control of human papillomavirus infections and related diseases. Vaccine. 2013, 31 (6): G1-G31.
  6. Crowe E., Pandeya N., Brotherton J.M. et al. Effectiveness of quadrivalent human papillomavirus vaccine for the prevention of cervical abnormalities: case-control study nested within a population based screening programme in Australia. BMJ. 2014, 348: g1458.
  7. de Villiers E.M., Fauquet C., Bernard H.U. et al. Classification of papillomaviruses. Virology. 2004, 324: 17-27.
  8. de Vuyst H., Clifford G.M., Nascimento M.C. et al. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int. J. Cancer. 2009, 124: 1626-1636.
  9. Doorbar J., Quint W., Banks L. et al. The biology and life-cycle of human papillomaviruses. Vaccine. 2012, 30 (5): F55-70.
  10. Fehrmann F., Laimins L.A. Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation. Oncogene. 2003, 22: 5201-5207.
  11. Forman D., de Martel C., Lacey C.J. et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012, 30 (5): F12-F23.
  12. Gross G., Pfister H. Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med. Microbiol. Immunol. 2004, 193: 35-44.
  13. Hernandez B.Y., Shvetsov Y.B., Goodman M.T. et al. Genital and extra-genital warts increase the risk of asymptomatic genital human papillomavirus infection in men. Sex. Transm. Infect. 2011, 87: 391-395.
  14. International Human Papillomavirus Reference Center. Available at: www.http://hpvcenter. se.
  15. Jablonska S., Majewski S., Obalek S. et al. Cutaneous warts. Clin. Dermatol. 1997, 15 (3): 309-319.
  16. Lacey C.J., Lowndes C.M., Shah K.V. Chapter 4: Burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease. Vaccine. 2006, 24 (3): S3/35-S3/41.
  17. Leigh I.M., Buchanan J.A., Harwood C.A. et al. Role of human papillomaviruses in cutaneous and oral manifestations of immunosuppression. J. Acq. Immune Def. Syndr. 1999, 21 (1): S49-S57.
  18. Li N., Franceschi S., Howell-Jones R. et al. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication. Int. J. Cancer. 2011, 128 (4): 927-935.
  19. Munoz N., Bosch F.X., de Sanjose S. et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med. 2003, 348: 518-527.
  20. Ndiaye C., Mena M., Alemany L. et al. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 2014, 15 (12): 1319-1331.
  21. Oriel J.D. Natural history of genital warts. Br. J. Vener. Dis. 1971, 47: 1-13.
  22. Patel H., Wagner M., Singhal P. et al. Systematic review of the incidence and prevalence of genital warts. BMC Infect. Dis. 2013, 13: 39.
  23. Rogovskaya S.I., Shabalova I.P., Mikheeva I.V. et al. Human papillomavirus prevalence and type-distribution, cervical cancer screening practices and current status of vaccination implementation in Russian Federation, the Western Countries of the former Soviet Union Caucasus Region and Central Asia. Vaccine. 2013, 31 (7): H46-H58.
  24. Schiffman M. H., Bauer H. M., Hoover R. N. et al. Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J. Nat. Cancer Institute. 1993, 85 (12): 958-964.
  25. World cancer report 2014 (ed. Bernard W. et al.), 2014.
  26. Zur Hausen H. Papillomaviruses in the causation of human cancers-a briefhistorical account. Virology. 2009, 384 (2): 260-265.
  27. Zur Hausen H. Papillomaviruses and cancer: From basic studies to clinical application. Nat. Rev. Cancer. 2002, 2: 342-350.
  28. Zur Hausen H. The search for infectious causes of human cancers: where and why. Virology. 2009, 392: 1-10.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Lopukhov P.D., Briko N.I., Khaldin A.A., Tsapkova N.N., Lupashko O.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС77-75442 от 01.04.2019 г.